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Inhibitory effects of anthocyanin on oxidative stress injury and epithelial-mesenchymal transition of human lens epithelial cells
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Wan-yi ZHOU1, Yi-xiu ZHAO1, Na AN2, Yun-long BAI1, Yan ZHANG1, *, Bao-feng YANG1
Acta Pharmaceutica Sinica | 2018, 53(4) : 538 - 545
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Acta Pharmaceutica Sinica | 2018, 53(4): 538-545
• ORIGINAL ARTICLES·Pharmacology •
Inhibitory effects of anthocyanin on oxidative stress injury and epithelial-mesenchymal transition of human lens epithelial cells
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Wan-yi ZHOU1, Yi-xiu ZHAO1, Na AN2, Yun-long BAI1, Yan ZHANG1, *, Bao-feng YANG1
Affiliations
  • 1. State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150081, China
  • 2. Heilongjiang Medical Academy, Harbin Medical University, Harbin 150081, China
Published: 2018-04-12 doi: 10.16438/j.0513-4870.2017-1004
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Anthocyanin is a water-soluble flavonoid pigment which is widely found in plants. Studies showed that anthocyanin had protective effect on vision. However, whether anthocyanin has therapeutic effect on cataract remain unclear. In this study, we established the age-related and posterior capsule opacification cataract cell models through inducing oxidative damage of human lens epithelial cells (HLECs) by H2O2 and inducing epithelial-mesenchymal transition (EMT) by transforming growth factor β2 (TGF-β2). The preventative effects of anthocyanin on markers of oxidative damage and EMT were determined by respective assay kits and PCR analysis. Anthocyanin was beneficial to reduce oxidative stress of HLECs, protecting cells from H2O2 induced damage and increasing α-crystallin expression. The potential mechanisms might be that anthocyanin increased the activities of SOD and GSH-Px, which contributes to reduce cellular ROS and MDA level. Besides, anthocyanin inhibited Ca2+ overload, which contributes to protection of cell from apoptosis. Meanwhile, anthocyanin had inhibitory effect on EMT, slowed down cell proliferation, migration caused by TGF-β2 through decreasing mRNA expression levels of EMT markers including COL1A1, COL1A2, COL3, COL4, Fn and α-SMA. The results suggest that anthocyanin could protect HLECs from oxidative damage induced by H2O2 and cell proliferation, migration and EMT induced by TGF-β2, which indicated that anthocyanin may have protective and therapeutic effects on age-related cataract and posterior capsule opacification.

anthocyanin  /  cataract  /  oxidative stress  /  epithelial-mesenchymal transition  /  cell proliferation
Wan-yi ZHOU, Yi-xiu ZHAO, Na AN, Yun-long BAI, Yan ZHANG, Bao-feng YANG. Inhibitory effects of anthocyanin on oxidative stress injury and epithelial-mesenchymal transition of human lens epithelial cells[J]. Acta Pharmaceutica Sinica, 2018 , 53 (4) : 538 -545 . DOI: 10.16438/j.0513-4870.2017-1004
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Article Info
doi: 10.16438/j.0513-4870.2017-1004
  • Receive Date：2017-10-15
  • Online Date：2026-01-15
  • Published：2018-04-12
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History
  • Received：2017-10-15
  • Revised：2017-12-06
Funding
Affiliations
    1. State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150081, China
    2. Heilongjiang Medical Academy, Harbin Medical University, Harbin 150081, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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