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Review and prospect on preparation technology of drug nanocrystals in the past thirty years
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Peng-fei YUE*, Yang LIU, Jin XIE, Ying-chong CHEN, Ming YANG*
Acta Pharmaceutica Sinica | 2018, 53(4) : 529 - 537
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Acta Pharmaceutica Sinica | 2018, 53(4): 529-537
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Review and prospect on preparation technology of drug nanocrystals in the past thirty years
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Peng-fei YUE*, Yang LIU, Jin XIE, Ying-chong CHEN, Ming YANG*
Affiliations
  • Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, State Key Laboratory of Innovative Drug and High Efficiency and Energy Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Published: 2018-04-12 doi: 10.16438/j.0513-4870.2017-0920
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Nanocrystals is a hot topic of poorly soluble drug delivery system under development. Nanocrystals is different from the nanoparticles for drug unloading in polymer materials, and nanocrystals is different from solid dispersion system, in which the drug maintains crystals state. Nanocrystals has a simple preparation process, represents an effective technology in the improvement of solubility and bioavailability of poorly soluble drugs, and has a very promising industrialization application and development potential. In this paper, we retrospect the development history of drug nanocrystals technology, review development of the preparation methods of nanocrystals, and analyze the existing problems to provide a reference to the development of drug nanocrystals preparation.

nanocrystal  /  preparation technology  /  bottom-up  /  top-down  /  combinative technology
Peng-fei YUE, Yang LIU, Jin XIE, Ying-chong CHEN, Ming YANG. Review and prospect on preparation technology of drug nanocrystals in the past thirty years[J]. Acta Pharmaceutica Sinica, 2018 , 53 (4) : 529 -537 . DOI: 10.16438/j.0513-4870.2017-0920
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Article Info
doi: 10.16438/j.0513-4870.2017-0920
  • Receive Date：2017-09-15
  • Online Date：2026-01-15
  • Published：2018-04-12
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History
  • Received：2017-09-15
  • Revised：2017-10-31
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    Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, State Key Laboratory of Innovative Drug and High Efficiency and Energy Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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