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Mechanism of apoptosis induced by SR1078 activating RORα in ovarian cancer cells
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Lin CHENG1, 2, Yu HOU1, 2, Wei-zhang WANG1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(1) : 62 - 67
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Acta Pharmaceutica Sinica | 2018, 53(1): 62-67
• ORIGINAL ARTICLES •
Mechanism of apoptosis induced by SR1078 activating RORα in ovarian cancer cells
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Lin CHENG1, 2, Yu HOU1, 2, Wei-zhang WANG1, 2, *
Affiliations
  • 1. School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2. Guangdong Province Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China
Published: 2018-01-12 doi: 10.16438/j.0513-4870.2017-0814
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This study was to investigate the effect of RORα activator SR1078 on ovarian cancer cells and its molecular mechanism in vitro. The survival rate of HeyA8 and Hey cells was detected by MTS assay; the apoptosis and cells cycle distribution after SR1078 treatment and the effect of p53 siRNA or PFT-α and PFT-β of p53 inhibitors on SR1078-induced apoptosis of HeyA8 or Hey cells were analyzed by flow cytometry. Western blot was used to detect the effect of SR1078 and p53 siRNA on the expression of p53 protein and the effect of p53 inhibitors alone or in combination with SR1078 on the expression of p53, p-p53 and its downstream pro-apoptotic protein Noxa. The results showed that SR1078 significantly reduced the cell viability and induced apoptosis in HeyA8 and Hey cells. In addition, SR1078 up-regulated the protein expression of p53 and Noxa, and p53 suppression led to significant inhibition of SR1078-induced apoptosis and the expression of Noxa in ovarian cancer cells. In summary, SR1078 induced apoptosis of ovarian cancer cells by activation of p53 signaling pathway.

retinoid acid receptor related orphan receptor α  /  N-[4-(1, 1, 1, 3, 3, 3-hexafluoro-2-hydroxypro-pan-2-yl)phenyl]-4-(trifluoromethyl)benzamide  /  ovarian neoplasms  /  p53  /  apoptosis
Lin CHENG, Yu HOU, Wei-zhang WANG. Mechanism of apoptosis induced by SR1078 activating RORα in ovarian cancer cells[J]. Acta Pharmaceutica Sinica, 2018 , 53 (1) : 62 -67 . DOI: 10.16438/j.0513-4870.2017-0814
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Article Info
doi: 10.16438/j.0513-4870.2017-0814
  • Receive Date：2017-08-20
  • Online Date：2026-01-15
  • Published：2018-01-12
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  • Received：2017-08-20
  • Revised：2017-09-18
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    1. School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China
    2. Guangdong Province Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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