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Advances in strategies of improving solubility and permeability of taxanes
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Tian-yun HAO1, Yuan-feng WEI1, Shuai QIAN1, Jian-jun ZHANG2, Yuan GAO1, *
Acta Pharmaceutica Sinica | 2018, 53(1) : 54 - 61
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Acta Pharmaceutica Sinica | 2018, 53(1): 54-61
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Advances in strategies of improving solubility and permeability of taxanes
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Tian-yun HAO1, Yuan-feng WEI1, Shuai QIAN1, Jian-jun ZHANG2, Yuan GAO1, *
Affiliations
  • 1. School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China
  • 2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Published: 2018-01-12 doi: 10.16438/j.0513-4870.2017-0863
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As a new generation of anti-tumor drugs, taxanes has a good clinical efficacy in the treatment of ovarian cancer, breast cancer, non-small cell lung cancer, head and neck cancer. However, low bioavailability of oral administration from low water solubility and low permeability significantly limited the development of their oral applications. Currently, the marketed preparations were non-oral drug preparations, and the injection contained a large number of surfactants (cremophor EL or Tween 80) and organic solvents (ethanol), which could result in fluid retention, hypersensitivity and other side effects, as well as poor compliance. Oral preparation will be an ideal form for development of taxanes medicines. According to the research by our and other groups in recent years, we investigate the technical strategies enhancing the water solubility and absorptive permeability to improve their oral bioavailability. Among them, we emphasize the application prospects of crystallography technology, and provide a theoretical basis to guide future research in the development of oral preparations for taxanes.

taxanes  /  oral preparation  /  low solubility  /  low permeability
Tian-yun HAO, Yuan-feng WEI, Shuai QIAN, Jian-jun ZHANG, Yuan GAO. Advances in strategies of improving solubility and permeability of taxanes[J]. Acta Pharmaceutica Sinica, 2018 , 53 (1) : 54 -61 . DOI: 10.16438/j.0513-4870.2017-0863
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Article Info
doi: 10.16438/j.0513-4870.2017-0863
  • Receive Date：2017-09-04
  • Online Date：2026-01-15
  • Published：2018-01-12
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History
  • Received：2017-09-04
  • Revised：2017-09-22
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    1. School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China
    2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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