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Role of carboxylesterase in drug metabolism
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Rui WANG, Jian-wei JIANG, Yan LI*
Acta Pharmaceutica Sinica | 2018, 53(2) : 186 - 191
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Acta Pharmaceutica Sinica | 2018, 53(2): 186-191
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Role of carboxylesterase in drug metabolism
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Rui WANG, Jian-wei JIANG, Yan LI*
Affiliations
  • Department of Drug Metabolism, Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2018-02-12 doi: 10.16438/j.0513-4870.2017-0901
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Carboxylesterases (CESs) belong to the esterase family, which are mainly responsible for catalyzing metabolism of a variety of drug as well as endogenous and exogenous compounds. CESs are widely distributed in the body, mainly expressed in lung, liver, intestine, kidney, skin epithelial cells, etc. There are significant species differences in the expression of CESs, which results in the difference on the drug metabolism with genetic polymorphism. In this paper, an overview of the classification and distribution, physiological function and mechanism, species differences and gene polymorphism of CESs are provided for the research of CESs and drug design.

carboxylesterase  /  pharmacokinetics  /  species difference  /  gene polymorphism
Rui WANG, Jian-wei JIANG, Yan LI. Role of carboxylesterase in drug metabolism[J]. Acta Pharmaceutica Sinica, 2018 , 53 (2) : 186 -191 . DOI: 10.16438/j.0513-4870.2017-0901
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Year 2018 volume 53 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2017-0901
  • Receive Date：2017-09-12
  • Online Date：2026-01-15
  • Published：2018-02-12
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  • Received：2017-09-12
  • Revised：2017-10-24
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Affiliations
    Department of Drug Metabolism, Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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