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The progress of multifunctional envelope-type nano device
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Li-ping YANG1, Li CAO2, Ting ZHAO1, Qing DU1, De-ying CAO1, Bai XIANG1, *, Jun-xia XIE3, *
Acta Pharmaceutica Sinica | 2018, 53(1) : 47 - 53
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Acta Pharmaceutica Sinica | 2018, 53(1): 47-53
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The progress of multifunctional envelope-type nano device
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Li-ping YANG1, Li CAO2, Ting ZHAO1, Qing DU1, De-ying CAO1, Bai XIANG1, *, Jun-xia XIE3, *
Affiliations
  • 1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2. Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China
  • 3. Department of Pharmaceutical, Hebei Chemical and pharmaceutical College, Shijiazhuang 050026, China
Published: 2018-01-12 doi: 10.16438/j.0513-4870.2017-0724
Outline
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The key of gene therapy is to deliver the functional gene to the target tissue in the body. The safe and efficient gene carrier is particularly important in the targeted delivery. Multifunctional envelope-type nano device (MEND), based on concept "Programmed packaging", is a new type of gene carrier system, with high encapsulation efficiency, favourable stability, high transfection efficiency, easy preparation, etc. MEND is designed to control intracellular trafficking as well as the tissue distribution of encapsulated compounds such as nucleic acids/proteins/peptides, permitting them to function at the appropriate location. In this paper, research progresses in MEND are reviewed in accordance with three types of payloads:the small interfering RNA (siRNA), DNA and proteins/peptides in recent years.

multifunctional envelope-type nano device  /  gene vector  /  siRNA  /  DNA  /  peptides
Li-ping YANG, Li CAO, Ting ZHAO, Qing DU, De-ying CAO, Bai XIANG, Jun-xia XIE. The progress of multifunctional envelope-type nano device[J]. Acta Pharmaceutica Sinica, 2018 , 53 (1) : 47 -53 . DOI: 10.16438/j.0513-4870.2017-0724
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Article Info
doi: 10.16438/j.0513-4870.2017-0724
  • Receive Date：2017-07-23
  • Online Date：2026-01-15
  • Published：2018-01-12
Article Data
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History
  • Received：2017-07-23
  • Revised：2017-09-12
Funding
Affiliations
    1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2. Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China
    3. Department of Pharmaceutical, Hebei Chemical and pharmaceutical College, Shijiazhuang 050026, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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