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Associations of VDR polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients
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Li QIN1, Jia-li LI1, *, Xiao-man LIU1, Xu-tao CHEN2, Shu LIU3, Long-shan LIU2, Chang-xi WANG2, Min HUANG1, *
Acta Pharmaceutica Sinica | 2017, 52(5) : 760 - 765
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Acta Pharmaceutica Sinica | 2017, 52(5): 760-765
Associations of VDR polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients
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Li QIN1, Jia-li LI1, *, Xiao-man LIU1, Xu-tao CHEN2, Shu LIU3, Long-shan LIU2, Chang-xi WANG2, Min HUANG1, *
Affiliations
  • 1. Institute of Clinical Pharmacology, School of Pharmaceutical Sciences
  • 2. Department of Kidney Transplant, the First Affiliated Hospital
  • 3. Department of Pharmacy, Cancer Center, Sun Yat-sen University, Guangzhou 510080, China
Published: 2017-05-12 doi: 10.16438/j.0513-4870.2017-0125
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The paper was aimed to investigate the association of VDR polymorphisms with tacrolimus (FK506) concentration in Chinese renal transplant recipients. A total of 114 renal transplant recipients receiving tacrolimus were genotyped for VDR rs1540339 and rs2853559 by Agena Bioscience MassARRAY® system and CYP3A5*3 by PCR-RFLP method. Trough concentrations of tacrolimus on day 7 after renal transplantation were collected from clinical data. Statistical analysis was performed with Spearman's correlation, Mann-Whitney U test and Kruskal-Wallis H test. The dose-adjusted concentration of tacrolimus in VDR rs2853559 GA and GG carriers were considerably higher than that of AA carriers. After stratification by CYP3A5*3 genotypes, VDR rs2853559 GA and GG carriers had a higher dose-adjusted tacrolimus concentration than that in AA carriers in CYP3A5 nonexpresser. CYP3A5*3 and VDR rs2853559 explained 45.6% variability of tacrolimus C0/D. In CYP3A5 non-expressers, VDR rs2853559 explained 14.4% variability of tacrolimus C0/D. The results illustrated that VDR rs2853559 polymorphisms was associated with tacrolimus concentrations, and the determination of this SNP may be useful for individualized medicine of tacrolimus.

tacrolimus  /  VDR  /  polymorphism  /  renal transplantation
Li QIN, Jia-li LI, Xiao-man LIU, Xu-tao CHEN, Shu LIU, Long-shan LIU, Chang-xi WANG, Min HUANG. Associations of VDR polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients[J]. Acta Pharmaceutica Sinica, 2017 , 52 (5) : 760 -765 . DOI: 10.16438/j.0513-4870.2017-0125
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Article Info
doi: 10.16438/j.0513-4870.2017-0125
  • Receive Date：2017-02-13
  • Online Date：2026-01-14
  • Published：2017-05-12
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  • Received：2017-02-13
  • Revised：2017-03-16
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Affiliations
    1. Institute of Clinical Pharmacology, School of Pharmaceutical Sciences
    2. Department of Kidney Transplant, the First Affiliated Hospital
    3. Department of Pharmacy, Cancer Center, Sun Yat-sen University, Guangzhou 510080, China
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https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2017-0125
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表12种不同金属材料的力学参数
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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