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Combination chemotherapy of L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride with anti-cancer drugs in human hepatocellular carcinoma
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Qiong-ying HU1, 3, Jian-dong JIANG2, 3, Dan-qing SONG3, Yong LIANG1, *, Yan-xing HAN2, *
Acta Pharmaceutica Sinica | 2017, 52(6) : 911 - 920
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Acta Pharmaceutica Sinica | 2017, 52(6): 911-920
• ORIGINAL ARTICLES·Pharmacology •
Combination chemotherapy of L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride with anti-cancer drugs in human hepatocellular carcinoma
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Qiong-ying HU1, 3, Jian-dong JIANG2, 3, Dan-qing SONG3, Yong LIANG1, *, Yan-xing HAN2, *
Affiliations
  • 1. School of Medicine, Taizhou University, Taizhou 318000, China
  • 2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-06-12 doi: 10.16438/j.0513-4870.2017-0441
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L-Proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride (MF13) is a new anticancer tripeptide. Our previous study in vitro and in vivo showed that MF13 had anti-proliferative activities in a panel of human hepatocellular carcinoma (HCC) cell lines from different origin. In the present study, we focused on the inhibition effect on HCC of MF13 combined with other anti-cancer drugs. The results of combination chemotherapy in vitro indicated that the combination of MF13 with mitomycin C (MMC) at appropriate concentrations led to a synergistic effect; however, the combination of MF13 with vincristine (VCR) showed no synergistic effect. In the Bel-7402 tumor bearing nude mice, the antitumor effect of the groups of 2 mg·kg-1 MF13 + 2 mg·kg-1 MMC or 2 mg·kg-1 MF13 + 50 mg·kg-1 cyclophosphamide (CTX) exhibited synergistic anticancer efficacies while the group of 2 mg·kg-1 MF13 + 0.3 mg·kg-1 VCR did not have the same effect. Based on our data, we believe that MF13 can be considered as a potential agent against human hepatocellular carcinoma no matter how treated, alone or combined with other drugs.

hepatocellular carcinoma  /  mechlorethamine  /  combined chemotherapy  /  drug synergism
Qiong-ying HU, Jian-dong JIANG, Dan-qing SONG, Yong LIANG, Yan-xing HAN. Combination chemotherapy of L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride with anti-cancer drugs in human hepatocellular carcinoma[J]. Acta Pharmaceutica Sinica, 2017 , 52 (6) : 911 -920 . DOI: 10.16438/j.0513-4870.2017-0441
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Year 2017 volume 52 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2017-0441
  • Receive Date：2017-05-03
  • Online Date：2026-01-14
  • Published：2017-06-12
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History
  • Received：2017-05-03
  • Revised：2017-05-22
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Affiliations
    1. School of Medicine, Taizhou University, Taizhou 318000, China
    2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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