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Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system
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Yue YU1, 2, Chun TAO1, Hai-yue YANG1, 3, Tian-yu WANG1, 3, Dan-ping XUE1, Xue-mei TIAN1, Mei-jing ZHANG1, 2, Sheng-nan FANG1, 2, Hong-tao SONG1, *
Acta Pharmaceutica Sinica | 2017, 52(6) : 985 - 991
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Acta Pharmaceutica Sinica | 2017, 52(6): 985-991
• ORIGINAL ARTICLES·Pharmaceutics •
Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system
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Yue YU1, 2, Chun TAO1, Hai-yue YANG1, 3, Tian-yu WANG1, 3, Dan-ping XUE1, Xue-mei TIAN1, Mei-jing ZHANG1, 2, Sheng-nan FANG1, 2, Hong-tao SONG1, *
Affiliations
  • 1. Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China
  • 2. College of Pharmacy, Fujian Medical University, Fuzhou 350108, China
  • 3. Medical College, Xiamen University, Xiamen 360000, China
Published: 2017-06-12 doi: 10.16438/j.0513-4870.2016-1198
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The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6±1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2:1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.

sirolimus  /  mesoporous silica nanoparticle  /  self-microemulsifying drug delivery system  /  solidification  /  nano-carrier  /  in vitro dissolution rate
Yue YU, Chun TAO, Hai-yue YANG, Tian-yu WANG, Dan-ping XUE, Xue-mei TIAN, Mei-jing ZHANG, Sheng-nan FANG, Hong-tao SONG. Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system[J]. Acta Pharmaceutica Sinica, 2017 , 52 (6) : 985 -991 . DOI: 10.16438/j.0513-4870.2016-1198
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Article Info
doi: 10.16438/j.0513-4870.2016-1198
  • Receive Date：2016-12-19
  • Online Date：2026-01-14
  • Published：2017-06-12
Article Data
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History
  • Received：2016-12-19
  • Revised：2017-02-04
Funding
Affiliations
    1. Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China
    2. College of Pharmacy, Fujian Medical University, Fuzhou 350108, China
    3. Medical College, Xiamen University, Xiamen 360000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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