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Novel antifungal agents against cryptococcal infections
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Guo-jian LIAO1, Jiao ZHENG1, Yu-qi HUANG1, Chen FU1, Jian-ping XIE2, *
Acta Pharmaceutica Sinica | 2017, 52(6) : 859 - 864
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Acta Pharmaceutica Sinica | 2017, 52(6): 859-864
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Novel antifungal agents against cryptococcal infections
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Guo-jian LIAO1, Jiao ZHENG1, Yu-qi HUANG1, Chen FU1, Jian-ping XIE2, *
Affiliations
  • 1. Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China
  • 2. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of life Sciences, Southwest University, Chongqing 400715, China
Published: 2017-06-12 doi: 10.16438/j.0513-4870.2016-1228
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Cryptococcal meningitis, caused by fungus Cryptococcus neoformans, is responsible for over a million infections and 600 000 deaths annually. Largely due to the limited treatment options and the intrinsic drawbacks coupled with drug resistance to current therapies, it is urgent to discover novel antifungal agents against cryptococcosis. An ideal antifungal drug should at least satisfy the following criteria: fungicidal, fungus-specific, permeable for the host barriers such as cell membranes of phagocytes and the blood-CNS barrier. Both discovery of candidates with novel mode of action and repurposing existing molecules with potent anti-cryptococcal activity are effective ways in discovery of new anti-cryptococcal agents. Here, we summarized recent advances in the study of anti-fungal activities, mechanisms of action, and clinical developments of new anti-cryptococcal drugs.

C. neoformans  /  cryptococcosis  /  cryptococcal meningitis  /  high-throughput screening  /  drug repurposing  /  sertraline
Guo-jian LIAO, Jiao ZHENG, Yu-qi HUANG, Chen FU, Jian-ping XIE. Novel antifungal agents against cryptococcal infections[J]. Acta Pharmaceutica Sinica, 2017 , 52 (6) : 859 -864 . DOI: 10.16438/j.0513-4870.2016-1228
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Article Info
doi: 10.16438/j.0513-4870.2016-1228
  • Receive Date：2016-12-27
  • Online Date：2026-01-14
  • Published：2017-06-12
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  • Received：2016-12-27
  • Revised：2017-03-05
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Affiliations
    1. Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China
    2. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of life Sciences, Southwest University, Chongqing 400715, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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