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Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug
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Yun-qiu MIAO1, 2, Shu-fang HE2, Jin-ying LIANG2, Qin KE2, Xin-xin ZHANG2, *, Rui WANG1, *, Yong GAN2
Acta Pharmaceutica Sinica | 2017, 52(6) : 977 - 984
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Acta Pharmaceutica Sinica | 2017, 52(6): 977-984
• ORIGINAL ARTICLES·Pharmaceutics •
Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug
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Yun-qiu MIAO1, 2, Shu-fang HE2, Jin-ying LIANG2, Qin KE2, Xin-xin ZHANG2, *, Rui WANG1, *, Yong GAN2
Affiliations
  • 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Published: 2017-06-12 doi: 10.16438/j.0513-4870.2017-0052
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This study aims to prepare lipid bilayer-coated calcium phosphate core-shell nanoparticles (LCAPNs), which can dissolve in an acidic environment to improve the tumor cell toxicity of antitumor drug. Paclitaxel (PTX) loaded lipid coated calcium phosphate nanoparticles (PTX-LCAPNs) were prepared by thin-film dispersion method. The morphology, particle size and in vitro release behavior were characterized. Meanwhile, the intracellular uptake, intracellular dissolution, cell toxicity of PTX-LCAPNs and intracellular accumulation of PTX were evaluated in human HCC cell line (Huh-7). The results suggested that the mean diameter of the spherical LCAPNs was 124.73±6.41 nm. The PTX-LCAPNs demonstrated little drug leakage in simulated normal physiological conditions, while a rapid release was observed in simulated intracellular condition in vitro. Moreover, the PTX-LCAPNs achieved 1.7 fold improvement in the intracellular PTX concentration leading to 5-fold reduction in half maximal inhibitory concentration (IC50) values of PTX compared with calcium phosphate nanoparticles loaded with PTX (PTX-CAPNs), demonstrating a stronger cancer cell lethality.

calcium phosphate  /  nanoparticle  /  paclitaxel  /  drug release  /  antitumor drug
Yun-qiu MIAO, Shu-fang HE, Jin-ying LIANG, Qin KE, Xin-xin ZHANG, Rui WANG, Yong GAN. Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug[J]. Acta Pharmaceutica Sinica, 2017 , 52 (6) : 977 -984 . DOI: 10.16438/j.0513-4870.2017-0052
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Year 2017 volume 52 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2017-0052
  • Receive Date：2017-01-12
  • Online Date：2026-01-14
  • Published：2017-06-12
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  • Received：2017-01-12
  • Revised：2017-03-01
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    1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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