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Research on compaction behavior of pharmaceutical powders based on surface free energy
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Liang-shan MING1, Zhe LI1, 2, Fei WU1, You-jie WANG1, Ruo-fei DU1, *, Li-jie ZHAO1, Yi FENG1, *
Acta Pharmaceutica Sinica | 2017, 52(7) : 1170 - 1177
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Acta Pharmaceutica Sinica | 2017, 52(7): 1170-1177
• ORIGINAL ARTICLES •
Research on compaction behavior of pharmaceutical powders based on surface free energy
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Liang-shan MING1, Zhe LI1, 2, Fei WU1, You-jie WANG1, Ruo-fei DU1, *, Li-jie ZHAO1, Yi FENG1, *
Affiliations
  • 1. Engineering Research Center of Modern Preparation of TCM, Ministry of Education, Shanghai 201203, China
  • 2. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2017-07-12 doi: 10.16438/j.0513-4870.2017-0087
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This study was designed to establish the method of characterization of surface free energy(SFE)and evaluate the compaction properties of pharmaceutical materials based on SFE. We investigated the contact angles of materials with water and diiodomethane under different compression pressures. The contact angles of materials at 353 MPa compression pressure were utilized to calculate the related parameters of SFE ultimately. The area under tensile strength-compression pressure curve(AUTSC)and pressure yield(Py)were employed to evaluate the compactibility of material. Additionally, Pearson correlation analysis was utilized to analyze the relationship between the SFE and the compaction properties of pharmaceutical materials. The results exhibited that SFE had a significant correlation with the compaction properties of materials(P < 0.05). Moreover, the related parameters of SFE, i.e., cohesive work(Wco)and polarity index(PI)of SFE, were positively correlated with Py of Heckel equation and negatively related with AUTSC. The higher values of Wco and PI, the stronger repulsive force among the particles, led to a worse compaction behavior. In this study, we established the method for characterization of the compaction behavior of materials based on SFE initially. This study also demonstrated that SFE could evaluate the compaction behavior effectively, which provides a better understanding of compaction behavior for pharmaceutical researchers.

surface free energy  /  Heckel equation  /  tensile strength  /  contact angle  /  cohesion work  /  correlation analysis
Liang-shan MING, Zhe LI, Fei WU, You-jie WANG, Ruo-fei DU, Li-jie ZHAO, Yi FENG. Research on compaction behavior of pharmaceutical powders based on surface free energy[J]. Acta Pharmaceutica Sinica, 2017 , 52 (7) : 1170 -1177 . DOI: 10.16438/j.0513-4870.2017-0087
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Year 2017 volume 52 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2017-0087
  • Receive Date：2017-01-19
  • Online Date：2026-01-14
  • Published：2017-07-12
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History
  • Received：2017-01-19
  • Revised：2017-03-17
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Affiliations
    1. Engineering Research Center of Modern Preparation of TCM, Ministry of Education, Shanghai 201203, China
    2. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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