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Stability of the new type of L. Bulgaricus microcapsule
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Yi-xian ZHOU1, Feng LI1, 2, Bei WANG1, Jing-tian CHEN1, Ying HUANG1, Xin PAN1, *, Ge LI2, Hang-ping CHEN2, Min FENG1, Chuan-bin WU1
Acta Pharmaceutica Sinica | 2017, 52(7) : 1165 - 1169
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Acta Pharmaceutica Sinica | 2017, 52(7): 1165-1169
• ORIGINAL ARTICLES •
Stability of the new type of L. Bulgaricus microcapsule
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Yi-xian ZHOU1, Feng LI1, 2, Bei WANG1, Jing-tian CHEN1, Ying HUANG1, Xin PAN1, *, Ge LI2, Hang-ping CHEN2, Min FENG1, Chuan-bin WU1
Affiliations
  • 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
  • 2. Guangzhou Neworld Pharmaceutical Co., Ltd., Guangzhou 510006, China
Published: 2017-07-12 doi: 10.16438/j.0513-4870.2017-0026
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A new type of L. Bulgaricus microcapsule was prepared to improve stability and resistance of L.Bulgaricus probiotics in harsh environments. An optimal method of preparation of L. Bulgaricus microcapsule is as follow. L. Bulgaricus was mixed with 3% alginate solution. The concentration of bacterial suspension was 1×109 cfu·mL-1. The mixture was microencapsulated by extrusion into 2% CaCl2 solution with a dispensing equipment. After 30 min solidification, the gel beads were lyophilized to obtain L.Bulgaricus microcapsules. The microencapsulation technology was aimed to improve the stability and survival rate of L. Bulgaricus. The microcapsule was spherical with uniform particle size and intact structure. The tolerance of acid, high temperature, high humidity and the long-term stability of freeze-dried powder and microcapsule were evaluated. The results indicated that microencapsulation technic could greatly improve stability and resistance of L. Bulgaricus probiotics in harsh environments.

probiotics  /  lactobacillus  /  capsule  /  drug stability
Yi-xian ZHOU, Feng LI, Bei WANG, Jing-tian CHEN, Ying HUANG, Xin PAN, Ge LI, Hang-ping CHEN, Min FENG, Chuan-bin WU. Stability of the new type of L. Bulgaricus microcapsule[J]. Acta Pharmaceutica Sinica, 2017 , 52 (7) : 1165 -1169 . DOI: 10.16438/j.0513-4870.2017-0026
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Article Info
doi: 10.16438/j.0513-4870.2017-0026
  • Receive Date：2017-01-06
  • Online Date：2026-01-14
  • Published：2017-07-12
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  • Received：2017-01-06
  • Revised：2017-02-22
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    1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
    2. Guangzhou Neworld Pharmaceutical Co., Ltd., Guangzhou 510006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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