Home Journals Articles Updates About
CN
image
收藏切换
Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease
收藏切换
PDF
Li-min SUN1, 2, 3, Li-fang LIU1, *, Hua-xu ZHU2, 3, *, Bao-jie ZHU2, 3, Qi-chun ZHANG2, 3
Acta Pharmaceutica Sinica | 2017, 52(8) : 1268 - 1275
Less
收藏切换
Acta Pharmaceutica Sinica | 2017, 52(8): 1268-1275
• ORIGINAL ARTICLES •
Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease
Full
Li-min SUN1, 2, 3, Li-fang LIU1, *, Hua-xu ZHU2, 3, *, Bao-jie ZHU2, 3, Qi-chun ZHANG2, 3
Affiliations
  • 1. The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
  • 2. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210029, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0144
Outline
收藏切换

This study was designed to explore the "multi-components, multi-targets and multi-pathways" intervention mechanism of Huanglian Jiedu decoction (HLJDD) in the treatment of Alzheimer's disease (AD) by pharmacological network technology, which may establish a foundation for drug development and innovative research. Seventeen active constituents of HLJDD with anti-AD activities were submitted to PharmMapper and Molecule Annotation System (MAS 3.0) bioinformatics softwares to predict the target proteins and carry out related KEGG pathways annotation respectively. The network of "active compound-target-pathway" was constructed and analyzed using the Cytoscape 3.4.0 software. The results suggest that 47 pathways are affected by the 17 active components through 59 target proteins, in which 4 target proteins are related to AD and 2 pathways related to neuroinflammation, respectively. The effect of HLJDD on AD may be dependent on clearing/reducing β-amyloid protein, inhibiting Tau hyperphosphorylation, anti-inflammation and immunoregulation.

network pharmacology  /  Huanglian Jiedu decoction  /  Alzheimer's disease  /  mechanism  /  molecular docking
Li-min SUN, Li-fang LIU, Hua-xu ZHU, Bao-jie ZHU, Qi-chun ZHANG. Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1268 -1275 . DOI: 10.16438/j.0513-4870.2017-0144
Appendix
Less
Year 2017 volume 52 Issue 8
PDF
181
78
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2017-0144
  • Receive Date：2017-02-17
  • Online Date：2026-01-14
  • Published：2017-08-12
Article Data
Affiliations
History
  • Received：2017-02-17
  • Revised：2017-03-21
Funding
Affiliations
    1. The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
    2. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210029, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2017-0144
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House