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Effect of Huangqin Tang on serum metabolic profile in rats with ulcerative colitis based on UHPLC-MS
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Dun-fang WANG1, Yan-li WANG1, Yi-wei WANG2, Li-kun DU3, Ying TONG3, Xi CHEN3, Shan-shan GUO1, Hang-yu XU1, Xu-ran MA1, Tao LI4, Wei-peng YANG1, *
Acta Pharmaceutica Sinica | 2017, 52(8) : 1306 - 1312
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Acta Pharmaceutica Sinica | 2017, 52(8): 1306-1312
• ORIGINAL ARTICLES Pharmaceutical Analysis •
Effect of Huangqin Tang on serum metabolic profile in rats with ulcerative colitis based on UHPLC-MS
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Dun-fang WANG1, Yan-li WANG1, Yi-wei WANG2, Li-kun DU3, Ying TONG3, Xi CHEN3, Shan-shan GUO1, Hang-yu XU1, Xu-ran MA1, Tao LI4, Wei-peng YANG1, *
Affiliations
  • 1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. China Food and Drug Administration Institute of Executive Development, Beijing 100073, China
  • 3. Heilongjiang University of Chinese Medicine, Harbin 150040, China
  • 4. The Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0079
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The study is aimed to test the effect of Huangqin Tang (HQT) on serum metabolic profile in rats with ulcerative colitis, and explore its possible action mechanism for ulcerative colitis (UC) rats. The model of UC rats with cell immunoreactivity was made using a compound method (trinitrobenzene sulfonic acid plus ethanol). Rats were randomly divided into the control group, the model group, and HQT group. Ultra performance liquid chromatography tandem mass spectrometry (UHPLC-MS), principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were employed to analyze the metabolic profile among normal group, the model group, HQT group. Potential biomarkers were screened in the serum based on the variable importance projection (VIP) value > 1, P < 0.05. As compared with the normal group, 16 potential biomarkers such as valine, tryptophan, lactic acid and urea were found and identified in the serum of model group rats. As compared with the model group, a part of the biomarkers were restored nearly to a normal state after HQT administration for 10 days. Metabolomic analysis revealed that the HQT has a certain therapeutic effect in UC rats, and the mechanism may be related to regulation of lipid metabolism, amino acid metabolism and energy metabolism.

Huangqin Tang  /  metabolomics  /  serum  /  ulcerative colitis
Dun-fang WANG, Yan-li WANG, Yi-wei WANG, Li-kun DU, Ying TONG, Xi CHEN, Shan-shan GUO, Hang-yu XU, Xu-ran MA, Tao LI, Wei-peng YANG. Effect of Huangqin Tang on serum metabolic profile in rats with ulcerative colitis based on UHPLC-MS[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1306 -1312 . DOI: 10.16438/j.0513-4870.2017-0079
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Article Info
doi: 10.16438/j.0513-4870.2017-0079
  • Receive Date：2017-02-18
  • Online Date：2026-01-14
  • Published：2017-08-12
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History
  • Received：2017-02-18
  • Revised：2017-04-28
Funding
Affiliations
    1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2. China Food and Drug Administration Institute of Executive Development, Beijing 100073, China
    3. Heilongjiang University of Chinese Medicine, Harbin 150040, China
    4. The Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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