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Study on hypoglycemic activity of 9-substituted berberine derivatives in vitro
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Gang REN1, Ming-rui ZHANG2, Dan-qing SONG1, Jian-dong JIANG1, 3, Ying-hong LI1, *
Acta Pharmaceutica Sinica | 2017, 52(8) : 1282 - 1286
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Acta Pharmaceutica Sinica | 2017, 52(8): 1282-1286
• ORIGINAL ARTICLES Medicinal Chemistry •
Study on hypoglycemic activity of 9-substituted berberine derivatives in vitro
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Gang REN1, Ming-rui ZHANG2, Dan-qing SONG1, Jian-dong JIANG1, 3, Ying-hong LI1, *
Affiliations
  • 1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. School of Life Science, Liaoning Normal University, Dalian 116081, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0040
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The glucose consumption activity of 9-substitued analogues of berberine was evaluated in L6 myotubes. It was found that the introduction of an ethoxy group on the 9-position of berberine was beneficial for the activity. 9-Ethoxy berberine analogue 2a exhibited superior activity to berberine in multiple dose levels, and the activity of 2a was 5.4 times as high as that of berberine at the dose of 1.25 μmol·L-1. At the meantime, the potency on AMPK activation of 2a was 2.8 times of that of berberine at the dose of 10 μmol·L-1. Therefore, the compound 2a is a promising scaffold for further modification.

berberine analogues  /  glucose consumption  /  synthesis
Gang REN, Ming-rui ZHANG, Dan-qing SONG, Jian-dong JIANG, Ying-hong LI. Study on hypoglycemic activity of 9-substituted berberine derivatives in vitro[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1282 -1286 . DOI: 10.16438/j.0513-4870.2017-0040
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Article Info
doi: 10.16438/j.0513-4870.2017-0040
  • Receive Date：2017-01-10
  • Online Date：2026-01-14
  • Published：2017-08-12
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History
  • Received：2017-01-10
  • Revised：2017-01-27
Funding
Affiliations
    1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. School of Life Science, Liaoning Normal University, Dalian 116081, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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