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The application of poly (2-ethyl-2-oxazoline) in drug delivery system
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Juan MAO, Jian-ming LI, Jin-song DING*
Acta Pharmaceutica Sinica | 2017, 52(8) : 1235 - 1240
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Acta Pharmaceutica Sinica | 2017, 52(8): 1235-1240
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The application of poly (2-ethyl-2-oxazoline) in drug delivery system
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Juan MAO, Jian-ming LI, Jin-song DING*
Affiliations
  • School of Xiangya Pharmaceutical Sciences, Central South University, Changsha 410013, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0142
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Poly(2-ethyl-2-oxazoline) (PEOz), a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline, has the characteristics of low toxicity, biocompatibility, flexible chain, and modified expediently. PEOz is a potential substitute of polyethylene glycol (PEG) to render the ability of long-circulation, enhance cellular uptake and endosomal escape behaviors to PEOz modified drug delivery system. In this review, we summarized recent literature for the research progress of physicochemical properties, synthetic methods and the application of PEOz in drug delivery system.

poly(2-ethyl-2-oxazoline)  /  polyethylene glycol  /  pH-sensitive  /  thermosensitive  /  drug delivery system
Juan MAO, Jian-ming LI, Jin-song DING. The application of poly (2-ethyl-2-oxazoline) in drug delivery system[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1235 -1240 . DOI: 10.16438/j.0513-4870.2017-0142
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Article Info
doi: 10.16438/j.0513-4870.2017-0142
  • Receive Date：2017-02-17
  • Online Date：2026-01-14
  • Published：2017-08-12
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  • Received：2017-02-17
  • Revised：2017-03-30
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    School of Xiangya Pharmaceutical Sciences, Central South University, Changsha 410013, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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