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Bromodomain and extraterminal proteins-a novel class of therapeutic targets in epigenetics
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Jin-jing CHEN1, 2, Xiao-li ZHAO2, Zhen WANG2, *, Lin-feng CHEN1, *
Acta Pharmaceutica Sinica | 2017, 52(8) : 1209 - 1215
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Acta Pharmaceutica Sinica | 2017, 52(8): 1209-1215
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Bromodomain and extraterminal proteins-a novel class of therapeutic targets in epigenetics
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Jin-jing CHEN1, 2, Xiao-li ZHAO2, Zhen WANG2, *, Lin-feng CHEN1, *
Affiliations
  • 1. University of Illinois at Urbana-Champaign, Department of Biochemistry, Urbana 61801, USA
  • 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0143
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Bromodomain and extraterminal (BET) proteins are a class of proteins that can interpret epigenetic codes and play an important role in regulating gene transcription through identifying and binding acetylated histones or non-histones proteins. The BET inhibitors have emerged with good therapeutic effects in preclinical disease models such as cancer and inflammation. Some of them have entered clinical studies, demonstrating that there is considerable prospect for drug development with BET as a potential therapeutic target. This review briefly describes the structures and functions of the BET proteins, the BET inhibitors in various diseases, as well as molecular mechanisms involved.

bromodomain and extraterminal  /  bromodomain containing 4  /  epigenetics  /  therapeutic target  /  chromatin regulation
Jin-jing CHEN, Xiao-li ZHAO, Zhen WANG, Lin-feng CHEN. Bromodomain and extraterminal proteins-a novel class of therapeutic targets in epigenetics[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1209 -1215 . DOI: 10.16438/j.0513-4870.2017-0143
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Article Info
doi: 10.16438/j.0513-4870.2017-0143
  • Receive Date：2017-02-17
  • Online Date：2026-01-14
  • Published：2017-08-12
Article Data
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History
  • Received：2017-02-17
  • Revised：2017-03-30
Funding
Affiliations
    1. University of Illinois at Urbana-Champaign, Department of Biochemistry, Urbana 61801, USA
    2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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