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Role of kallistatin in protecting hepatic stellate cells against oxidation through inhibition of oxidative stress and activation of Akt-eNOS signaling
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Xiao-ping HUANG1, 2, Xiao WANG2, Xiao-lan XIE1, Wen-tao XU1, Hui-yong YANG2, Zhao-fa LI2, Jun-sheng LIN2, Yong DIAO2, *
Acta Pharmaceutica Sinica | 2017, 52(9) : 1397 - 1403
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Acta Pharmaceutica Sinica | 2017, 52(9): 1397-1403
• ORIGINAL ARTICLES •
Role of kallistatin in protecting hepatic stellate cells against oxidation through inhibition of oxidative stress and activation of Akt-eNOS signaling
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Xiao-ping HUANG1, 2, Xiao WANG2, Xiao-lan XIE1, Wen-tao XU1, Hui-yong YANG2, Zhao-fa LI2, Jun-sheng LIN2, Yong DIAO2, *
Affiliations
  • 1. College of Chemical Engineering and Materials Sciences, Quanzhou Normal University, Quanzhou 362000, China
  • 2. Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China
Published: 2017-09-12 doi: 10.16438/j.0513-4870.2017-0199
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The present study was aimed to investigate the role and mechanisms of kallistatin in protection against oxidative stress-induced hepatic stellate cell damage. The effects of kallistatin on the viability, the intracellular superoxide level and Akt, eNOS molecules were investigated in human hepatic stellate cell line LX-2 and the incompletely activated primary rat hepatic stellate cells. Two different oxidative-stress related models, the hydrogen peroxide model and the iron-overload model were used in the experiments. The results show that kallistatin protected the hepatic stellate cells from oxidative damage and repaired the cell damage by oxidative stress. The main mechanism is antioxidant activity of kallistatin, which can remove the oxidized substances inside the cells. On the other way, kallistatin activates Akt and eNOS molecules to generate the antioxidant effect. Our results help to explore new anti-fibrotic targets.

kallistatin  /  hepatic stellate cell  /  oxidation damage  /  liver fibrosis
Xiao-ping HUANG, Xiao WANG, Xiao-lan XIE, Wen-tao XU, Hui-yong YANG, Zhao-fa LI, Jun-sheng LIN, Yong DIAO. Role of kallistatin in protecting hepatic stellate cells against oxidation through inhibition of oxidative stress and activation of Akt-eNOS signaling[J]. Acta Pharmaceutica Sinica, 2017 , 52 (9) : 1397 -1403 . DOI: 10.16438/j.0513-4870.2017-0199
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Article Info
doi: 10.16438/j.0513-4870.2017-0199
  • Receive Date：2017-03-03
  • Online Date：2026-01-14
  • Published：2017-09-12
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History
  • Received：2017-03-03
  • Revised：2017-04-07
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Affiliations
    1. College of Chemical Engineering and Materials Sciences, Quanzhou Normal University, Quanzhou 362000, China
    2. Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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