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Identification of metabolites and pharmacokinetics of mogrol in rat plasma
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Shan-gui LIU1, 2, Xiao-jian DAI2, Da-fang ZHONG2, Chao-feng ZHANG1, *, Xiao-yan CHEN2, *
Acta Pharmaceutica Sinica | 2017, 52(9) : 1452 - 1457
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Acta Pharmaceutica Sinica | 2017, 52(9): 1452-1457
• ORIGINAL ARTICLES •
Identification of metabolites and pharmacokinetics of mogrol in rat plasma
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Shan-gui LIU1, 2, Xiao-jian DAI2, Da-fang ZHONG2, Chao-feng ZHANG1, *, Xiao-yan CHEN2, *
Affiliations
  • 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Published: 2017-09-15 doi: 10.16438/j.0513-4870.2017-0341
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Mogrol is the aglycone of seven kinds of mogrosides and siamenoside I. Mogrol has drawn more attention in recent years for its anti-leukemia and anti-diabetes activities. An ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method was applied to identify the main metabolites of mogrol in rat plasma. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for determination of the main components in rat plasma. After an oral administration of 100 mg·kg-1 mogrol in rats, 13 metabolites were detected along the main component of parent drug in the plasma. The major metabolites were oxidated and dehydrogenated products. In this study, mogrol was quantitative analyzed using lithium carbonate reagent with high sensitivity. The assay was linear in concentration range 5.00-1 000 ng·mL-1 with intra-and inter-day precision within 9.3% and accuracy in range of -4.5% to 2.9%. Mogrol was absorbed into the blood very fast after oral administration, and the time to reach maximum concentration (tmax) was 1.67 h. The half-life (t1/2) of mogrol in rats was 2.34 h, and the oral absolute bioavailability was 3.5%.

mogrol  /  UHPLC-Q-TOF/MS  /  metabolite  /  LC-MS/MS  /  pharmacokinetics
Shan-gui LIU, Xiao-jian DAI, Da-fang ZHONG, Chao-feng ZHANG, Xiao-yan CHEN. Identification of metabolites and pharmacokinetics of mogrol in rat plasma[J]. Acta Pharmaceutica Sinica, 2017 , 52 (9) : 1452 -1457 . DOI: 10.16438/j.0513-4870.2017-0341
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Article Info
doi: 10.16438/j.0513-4870.2017-0341
  • Receive Date：2017-04-09
  • Online Date：2026-01-14
  • Published：2017-09-15
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  • Received：2017-04-09
  • Revised：2017-06-20
Affiliations
    1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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