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The strategies of targeting therapy of hepatocellular carcinoma by adeno-associated virus
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San-xing GAO, Shuang-feng CAI*, Rui-an XU
Acta Pharmaceutica Sinica | 2017, 52(9) : 1359 - 1365
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Acta Pharmaceutica Sinica | 2017, 52(9): 1359-1365
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The strategies of targeting therapy of hepatocellular carcinoma by adeno-associated virus
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San-xing GAO, Shuang-feng CAI*, Rui-an XU
Affiliations
  • Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China
Published: 2017-09-12 doi: 10.16438/j.0513-4870.2017-0299
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Hepatocellular carcinoma (HCC) is the most common liver cancer, which is also the second leading cause of death in cancer. With the development of molecular biology and technology, gene therapy has become a new potential method to treat the cancer. As a viral gene-delivery system, the adeno-associated virus (AAV) is the most promising delivery vehicle for its high efficiency of infection, low pathogenicity and low immunogenicity. However, AAV has a wide range of host that may lead to side effects. Targeted gene therapy can achieve site-specific and high efficient gene expression, which avoids toxicity of systemic and non-targeted gene expression to improve the safety and efficacy of gene therapy. In this review, we provide an overview of the pathogenesis of HCC and the characteristics of AAV. Moreover, we discuss the targeting strategies currently employed in the gene therapy for HCC with a focus on targeting the transductional, transcriptional and posttranscriptional levels. New strategies are proposed for improving the quality of life and survival rate of patients with HCC.

hepatocellular carcinoma  /  molecular mechanism  /  adeno-associated virus  /  targeted therapy  /  gene therapy
San-xing GAO, Shuang-feng CAI, Rui-an XU. The strategies of targeting therapy of hepatocellular carcinoma by adeno-associated virus[J]. Acta Pharmaceutica Sinica, 2017 , 52 (9) : 1359 -1365 . DOI: 10.16438/j.0513-4870.2017-0299
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Article Info
doi: 10.16438/j.0513-4870.2017-0299
  • Receive Date：2017-04-01
  • Online Date：2026-01-14
  • Published：2017-09-12
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  • Received：2017-04-01
  • Revised：2017-05-09
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    Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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