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Signal transducers and activators of transcription (STAT3) is an important member of the family of signal transducers and activators of transcription, which plays a dual role in signaling and initiating gene transcription in cells. Numerous studies have demonstrated constitutive activation of STAT3 in a wide variety of human tumors. There is strong evidence to suggest that aberrant STAT3 signaling promotes initiation and progression of human cancers by either inhibition of apoptosis or induction of cell proliferation, angiogenesis, invasion, metastasis, inflammation and immunosuppression. At present, some specific small molecule inhibitors have been developed to target STAT3. However, no drugs have been used in the clinical stage. The identification and development of novel drugs that can target deregulated STAT3 activation effectively remains an important scientific and clinical challenge. This article provides a summary on progress about STAT3 in tumor genesis and new inhibitors of STAT3.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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