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Anti-inflammatory effect of TTF1-NP on lipopoiysaccharide stimulated human hepatocellular carcinoma cells
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Kui-yang SHAO, Xuan ZHANG, Wen-jun JIAO, Si-lin ZHANG, Xue-wu ZHANG*
Acta Pharmaceutica Sinica | 2017, 52(10) : 1549 - 1553
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Acta Pharmaceutica Sinica | 2017, 52(10): 1549-1553
• ORIGINAL ARTICLES •
Anti-inflammatory effect of TTF1-NP on lipopoiysaccharide stimulated human hepatocellular carcinoma cells
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Kui-yang SHAO, Xuan ZHANG, Wen-jun JIAO, Si-lin ZHANG, Xue-wu ZHANG*
Affiliations
  • Medical College, Yanbian University, Yanji 133002, China
Published: 2017-10-12 doi: 10.16438/j.0513-4870.2017-0432
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The study was designed to test the role of 5, 2', 4'-trihydroxy-6, 7, 5'-trimethoxy flavone nanoparticle (TTF1-NP) on lipopoiysaccharide (LPS)-induced inflammatory response, and to explore the anti-inflammatory mechanism in human hepatocellular carcinoma cells. Inflammatory responses were induced in human hepato-cellular carcinoma HepG2 cells with LPS; Proliferation effect of TTF1-NP in LPS-stimulated HepG2 cells were detected by MTT assay; The expression of TLR4, AKT/mTOR signaling related proteins and IL-6 were detected by Western blot assay. The results showed that TTF1-NP inhibited the proliferation of HepG2 cells induced by LPS in a dose-dependent manner; TTF1-NP inhibited the expression of TLR4, the activation of AKT and mTOR, and expression of IL-6 in a dose-dependent manner; TTF1-NP inhibited the activation of AKT/mTOR signaling pathway and TLR4 proteins leading to suppression of IL-6 expression in HepG2 cells stimulated by insulin. These results suggest that TTF1-NP inhibited inflammatory responses from LPS treatment with a potential mechanisms in the inhibition of AKT/mTOR pathway.

5, 2', 4'-trihydroxy-6, 7, 5'-trimethoxy flavone nanoparticle  /  liver cancer  /  inflammation  /  AKT/mTOR signaling pathway
Kui-yang SHAO, Xuan ZHANG, Wen-jun JIAO, Si-lin ZHANG, Xue-wu ZHANG. Anti-inflammatory effect of TTF1-NP on lipopoiysaccharide stimulated human hepatocellular carcinoma cells[J]. Acta Pharmaceutica Sinica, 2017 , 52 (10) : 1549 -1553 . DOI: 10.16438/j.0513-4870.2017-0432
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doi: 10.16438/j.0513-4870.2017-0432
  • Receive Date：2017-05-03
  • Online Date：2026-01-14
  • Published：2017-10-12
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  • Received：2017-05-03
  • Revised：2017-06-21
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    Medical College, Yanbian University, Yanji 133002, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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