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Identification of polygala oligosaccharide esters and their metabolites in rat plasma after oral administration of ethanol extract of Kai Xin San by UHPLC-MS
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Na WANG1, AHMAD Hassan1, Yong-ming JIA1, Di XUE1, CHAULAGAIN Ram1, Shu-ming HUANG2, Xue-wei LIU1, *
Acta Pharmaceutica Sinica | 2017, 52(10) : 1592 - 1598
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Acta Pharmaceutica Sinica | 2017, 52(10): 1592-1598
• ORIGINAL ARTICLES •
Identification of polygala oligosaccharide esters and their metabolites in rat plasma after oral administration of ethanol extract of Kai Xin San by UHPLC-MS
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Na WANG1, AHMAD Hassan1, Yong-ming JIA1, Di XUE1, CHAULAGAIN Ram1, Shu-ming HUANG2, Xue-wei LIU1, *
Affiliations
  • 1. Qiqihar Medical University, Qiqihar 161006, China
  • 2. Heilongjiang University of Chinese Medicine, Harbin 150040, China
Published: 2017-10-12 doi: 10.16438/j.0513-4870.2017-0373
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Using a UHPLC-TOF/MS method combined with software of Masslynx V4.1 and database in the literatures, a total of 20 polygala oligosaccharide esters (POEs) were identified in 60% ethanol extract of Kai Xin San (KXS-60%E). Furthermore, 14 POEs as well as 4 POE-metabolites were identified in rat plasma. The results revealed that POEs and POE-metabolites which were identified in rat plasma, were key components in KXS-60%E and the potential bioactive compounds for KXS action in the treatment of AD.

Kai Xin San  /  blood transitional component  /  polygala oligosaccharide ester  /  metabolite
Na WANG, AHMAD Hassan, Yong-ming JIA, Di XUE, CHAULAGAIN Ram, Shu-ming HUANG, Xue-wei LIU. Identification of polygala oligosaccharide esters and their metabolites in rat plasma after oral administration of ethanol extract of Kai Xin San by UHPLC-MS[J]. Acta Pharmaceutica Sinica, 2017 , 52 (10) : 1592 -1598 . DOI: 10.16438/j.0513-4870.2017-0373
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Article Info
doi: 10.16438/j.0513-4870.2017-0373
  • Receive Date：2017-04-17
  • Online Date：2026-01-14
  • Published：2017-10-12
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  • Received：2017-04-17
  • Revised：2017-06-30
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    1. Qiqihar Medical University, Qiqihar 161006, China
    2. Heilongjiang University of Chinese Medicine, Harbin 150040, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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