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Research progress in toxic effects of antitumor drugs based on drug transporter
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Jin-qi ZHENG1, 2, Xi YANG1, Qian WANG1, Jun ZHOU1, Yan LOU1, *, Su ZENG3
Acta Pharmaceutica Sinica | 2017, 52(10) : 1496 - 1504
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Acta Pharmaceutica Sinica | 2017, 52(10): 1496-1504
• REVIEWS •
Research progress in toxic effects of antitumor drugs based on drug transporter
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Jin-qi ZHENG1, 2, Xi YANG1, Qian WANG1, Jun ZHOU1, Yan LOU1, *, Su ZENG3
Affiliations
  • 1. The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China
  • 2. Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
  • 3. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Published: 2017-10-12 doi: 10.16438/j.0513-4870.2017-0470
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Differences of the individual toxic effects of antitumor drugs have been a concern in clinical treatment of cancers. The drug toxicity was not only related to the age, sex, and drug interactions, but also to the expression of protein involved in the metabolism, targets and transporters of drugs. Drug transporter mediates the absorption, distribution and elimination of some drugs, which exhibits a great significance in pharmacology and clinical practice. The purpose of this review is to provide information regarding trans-porter-medicated toxic effects of antitumor drugs in order to reduce or avoid the transporter-medicated toxic effects, and to promote reasonable drug use and individualized application of antitumor drugs in clinics.

antitumor drug  /  transporter  /  toxic effect  /  genetic polymorphism
Jin-qi ZHENG, Xi YANG, Qian WANG, Jun ZHOU, Yan LOU, Su ZENG. Research progress in toxic effects of antitumor drugs based on drug transporter[J]. Acta Pharmaceutica Sinica, 2017 , 52 (10) : 1496 -1504 . DOI: 10.16438/j.0513-4870.2017-0470
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doi: 10.16438/j.0513-4870.2017-0470
  • Receive Date：2017-06-10
  • Online Date：2026-01-14
  • Published：2017-10-12
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History
  • Received：2017-06-10
  • Revised：2017-07-19
Funding
Affiliations
    1. The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China
    2. Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
    3. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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