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Progress in study of antidepressants metabolism in vivo
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Feng ZHANG1, 2, 3, Xue-mei QIN1, 3, Guan-hua DU1, 4, Xiao-xia GAO1, 3, *
Acta Pharmaceutica Sinica | 2017, 52(12) : 1791 - 1800
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Acta Pharmaceutica Sinica | 2017, 52(12): 1791-1800
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Progress in study of antidepressants metabolism in vivo
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Feng ZHANG1, 2, 3, Xue-mei QIN1, 3, Guan-hua DU1, 4, Xiao-xia GAO1, 3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
  • 4. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2017-12-15 doi: 10.16438/j.0513-4870.2017-0478
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Depression is a complex heterogeneous psychiatric disorder with a potential to cause patient disability worldwide. In the past decades, a number of the first-line drugs (tricyclics, monoamine oxidase inhibitors, serotonin selective reuptake inhibitors, noradrenaline reuptake inhibitors, serotonin and noradrenaline reuptake inhibitors, etc.) had been discovered for the treatment of depression. CYP450 superfamily is involved in the biotransformation of antidepressants mainly through the CYP2D6, CYP2C19, CYP3A4 isoenzymes. Their genetic polymorphisms are closely related to clinical use and the interactions have been already identified between enzymes and antidepressants. This review focuses on drug metabolism and the interaction for CYP450 enzymes. The content may contribute to the development of antidepressant, improvement of the safety of antidepressants and the efficacy of treatment.

antidepressant  /  metabolism  /  metabolism enzyme  /  depression
Feng ZHANG, Xue-mei QIN, Guan-hua DU, Xiao-xia GAO. Progress in study of antidepressants metabolism in vivo[J]. Acta Pharmaceutica Sinica, 2017 , 52 (12) : 1791 -1800 . DOI: 10.16438/j.0513-4870.2017-0478
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Article Info
doi: 10.16438/j.0513-4870.2017-0478
  • Receive Date：2017-05-12
  • Online Date：2026-01-14
  • Published：2017-12-15
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History
  • Received：2017-05-12
  • Revised：2017-08-14
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
    4. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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