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Comparative study on quality of Scutellaria baicalensis Georgi in different harvest periods using UHPLC-MS/MS metabolomics technology
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Yi-yuan PANG1, 2, Li-ying XUE1, 2, Yan-hong ZHENG1, 2, Yu-zhi ZHOU1, *, Xue-mei QIN1, Guan-hua DU1, 3, Xiang ZHANG1, 4
Acta Pharmaceutica Sinica | 2017, 52(12) : 1903 - 1909
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Acta Pharmaceutica Sinica | 2017, 52(12): 1903-1909
• ORIGINAL ARTICLES •
Comparative study on quality of Scutellaria baicalensis Georgi in different harvest periods using UHPLC-MS/MS metabolomics technology
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Yi-yuan PANG1, 2, Li-ying XUE1, 2, Yan-hong ZHENG1, 2, Yu-zhi ZHOU1, *, Xue-mei QIN1, Guan-hua DU1, 3, Xiang ZHANG1, 4
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
  • 4. Department of Chemistry in University of Louisville, Louisville 40292, USA
Published: 2017-12-12 doi: 10.16438/j.0513-4870.2017-0466
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The quality of Scutellaria baicalensis Georgi has a close relationship to the harvest time. With the annual and biennial Scutellaria baicalensis Georgi in different harvest periods as samples, we detected the dynamic changes of chemical compositions in their contents by UHPLC-MS/MS metabolomics technology, then identified the biomarkers of different harvest periods and analyzed their changes in content, finally analyzed the correlation among different metabolites. The results showed that chemical compositions of different harvest periods were obviously different, and showed regular changes. According to the results, if the flavonoid aglycones are chosen as the target components, the proposed harvest time could be May. If flavonoid glycosides, the time is from July to August. Plant metabolomics methodology based on UHPLC-MS/MS can be used to detect the chemical compositions of Scutellaria baicalensis Georgi in different harvest periods, which provide a reference to the optimum harvest period of Scutellaria baicalensis Georgi, and also provide a new method of quality evaluation of traditional Chinese medicinal materials.

Scutellaria baicalensis Georgi  /  UHPLC-MS/MS  /  metabolomics  /  harvest period
Yi-yuan PANG, Li-ying XUE, Yan-hong ZHENG, Yu-zhi ZHOU, Xue-mei QIN, Guan-hua DU, Xiang ZHANG. Comparative study on quality of Scutellaria baicalensis Georgi in different harvest periods using UHPLC-MS/MS metabolomics technology[J]. Acta Pharmaceutica Sinica, 2017 , 52 (12) : 1903 -1909 . DOI: 10.16438/j.0513-4870.2017-0466
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Article Info
doi: 10.16438/j.0513-4870.2017-0466
  • Receive Date：2017-05-10
  • Online Date：2026-01-14
  • Published：2017-12-12
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  • Received：2017-05-10
  • Revised：2017-07-27
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
    4. Department of Chemistry in University of Louisville, Louisville 40292, USA
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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