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Qualitative and quantitative analysis of major constituents of raw and processed Arctii Fructus by UHPLC-UV-Q-TOF-MS/MS
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Jing HU1, Kun-ming QIN2, 3, Ting-ting ZHU1, Xiao-li WANG1, Meng-xue FAN1, Bao-chang CAI1, 2, 3, *
Acta Pharmaceutica Sinica | 2017, 52(4) : 603 - 608
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Acta Pharmaceutica Sinica | 2017, 52(4): 603-608
Qualitative and quantitative analysis of major constituents of raw and processed Arctii Fructus by UHPLC-UV-Q-TOF-MS/MS
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Jing HU1, Kun-ming QIN2, 3, Ting-ting ZHU1, Xiao-li WANG1, Meng-xue FAN1, Bao-chang CAI1, 2, 3, *
Affiliations
  • 1. Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co. Ltd, Nanjing 210061, China
  • 3. Nanjing Haichang Chinese Medicine Corporation, Nanjing 210061, China
Published: 2017-04-12 doi: 10.16438/j.0513-4870.2016-0967
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In this study, we developed a qualitative analytical method based on liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) for identification of multi-constituents of raw Fructus Arctii (RFA) and processed Fructus Arctii (PFA). We established a UHPLC-UV analytical method for simultaneously determining 6 major compounds in Fructus Arctii. UHPLC-Q-TOF-MS/MS qualitative analysis was performed under negative and positive ion modes and a total of 23 chemical compounds were identified. The analysis data were subjected to a principle component analysis with a t-test. Ten peaks were found to be the main difference (P < 0.05) between RFA and PFA. HPLC-UV quantitative method result showed the contents of 6 constituents were different between RFA and PFA. The results indicated that there was less arctiin, chlorogenic acid, isochlorogenic acid A in PFA than in RFA. However, there were higher levels of arctigenin, isochlorogenic acid B, isochlorogenic acid C in the PFA than RFA, which may be the main reason for different clinical efficacy of RFA and PFA.

Fructus Arctii  /  processing  /  UHPLC-Q-TOF-MS/MS  /  HPLC-UV  /  qualitative analysis  /  quantitative analysis
Jing HU, Kun-ming QIN, Ting-ting ZHU, Xiao-li WANG, Meng-xue FAN, Bao-chang CAI. Qualitative and quantitative analysis of major constituents of raw and processed Arctii Fructus by UHPLC-UV-Q-TOF-MS/MS[J]. Acta Pharmaceutica Sinica, 2017 , 52 (4) : 603 -608 . DOI: 10.16438/j.0513-4870.2016-0967
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Article Info
doi: 10.16438/j.0513-4870.2016-0967
  • Receive Date：2016-10-30
  • Online Date：2026-01-14
  • Published：2017-04-12
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History
  • Received：2016-10-30
  • Revised：2016-12-26
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Affiliations
    1. Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co. Ltd, Nanjing 210061, China
    3. Nanjing Haichang Chinese Medicine Corporation, Nanjing 210061, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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