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The miRNA microarray analysis of salidroside's anti-aging function in human embryonic lung fibroblast 2BS cells
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Jing ZHANG, Hui-li SU, Ya-zhen WANG, Xiao-lin WEN, Bing-bing JIA, Gen-xiang MAO*
Acta Pharmaceutica Sinica | 2017, 52(4) : 550 - 555
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Acta Pharmaceutica Sinica | 2017, 52(4): 550-555
• ORIGINAL ARTICLES Pharmacology •
The miRNA microarray analysis of salidroside's anti-aging function in human embryonic lung fibroblast 2BS cells
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Jing ZHANG, Hui-li SU, Ya-zhen WANG, Xiao-lin WEN, Bing-bing JIA, Gen-xiang MAO*
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  • Zhejiang Hospital, Hangzhou 310013, China
Published: 2017-04-12 doi: 10.16438/j.0513-4870.2016-1040
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This study was designed to investigate the microRNA expression profile in human embryonic lung fibroblast 2BS cells upon salidroside (SAL) treatment, and predict the target genes of miRNAs and related pathways delaying cellular senescence. Samples were divided into three groups: young control (28 PD), old control (50 PD), and old+SAL (50 PD with SAL), RNA from three groups was used for miRNA microarray analysis. In late PD cells, 43 miRNAs were found significantly changed relatively to those in young cells, and 58 miRNAs were regulated by SAL. The miRNAs including hsa-let-7c, hsa-let-7e and hsa-mir-3620 were significantly down-regulated in late PD cells which could be reversed by SAL treatment. However, hsa-mir-411, hsa-mir-24-2-5p and hsa-mir-485-3p exhibited an opposite trend. Gene Ontology and Pathway analysis revealed that target genes were significantly enriched in 31 GO and 11 pathways. The microarray data was further validated with qRT-PCR. This research provides new clues regarding the underlying mechanisms of SAL on cellular senescence through miRNAs regulation.

salidroside  /  senescence  /  miRNA microarray  /  fibroblast  /  let-7
Jing ZHANG, Hui-li SU, Ya-zhen WANG, Xiao-lin WEN, Bing-bing JIA, Gen-xiang MAO. The miRNA microarray analysis of salidroside's anti-aging function in human embryonic lung fibroblast 2BS cells[J]. Acta Pharmaceutica Sinica, 2017 , 52 (4) : 550 -555 . DOI: 10.16438/j.0513-4870.2016-1040
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doi: 10.16438/j.0513-4870.2016-1040
  • Receive Date：2016-10-27
  • Online Date：2026-01-14
  • Published：2017-04-12
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  • Received：2016-10-27
  • Revised：2016-11-24
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    Zhejiang Hospital, Hangzhou 310013, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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