Home Journals Articles Updates About
CN
image
收藏切换
Activating blood biological potency assay and chemical fingerprint chromatogram applied to quality evaluation of rhubarb
收藏切换
PDF
Hai-zhu ZHANG1, 2, Peng TAN3, Zhen-jie LIU2, Jian WANG4, Jia-bo WANG2, Xiao-he XIAO2, *
Acta Pharmaceutica Sinica | 2017, 52(3) : 436 - 442
Less
收藏切换
Acta Pharmaceutica Sinica | 2017, 52(3): 436-442
Activating blood biological potency assay and chemical fingerprint chromatogram applied to quality evaluation of rhubarb
Full
Hai-zhu ZHANG1, 2, Peng TAN3, Zhen-jie LIU2, Jian WANG4, Jia-bo WANG2, Xiao-he XIAO2, *
Affiliations
  • 1. Department of Pharmacy and Chemistry, Dali University, Dali 671000, China
  • 2. China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China
  • 3. Chengdu Institute for Food and Drug Control, Chengdu 610045, China
  • 4. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-0896
Outline
收藏切换

The biological potency assay and chemical fingerprint chromatogram were applied to quality evaluation of rhubarb. Using the biological potency as indicators, we evaluated the differences in quality of multiple batches of rhubarbs and related products. Using the platelet aggregation analyzer, we determined platelet aggregation rate in the different rhubarbs preparations, and calculated the biological potency based on the simplified probit principle. UPLC was adopted to establish the fingerprint spectra for rhubarbs. The spectral efficiency correlation analysis between chromatograms and biological potencies were conducted using the double variables of SPSS 22.0 software. We used three chemical composition to verify the potency. The biological potency results suggest that Rheum palmatum has a more potent activity than Rheum tanguticum, and wine-treated rhubarb had a higher potentcy than charred. We identified 10 elements in the Fingerprint Spectrum. The relevant elements including rhein-8-O-β-D-glucoside, emodin-8-O-β-D-glucoside and rhein have the strongest activity in the inhibition of platelet aggregation. In conclusion, this study provides a analytical method for rhubarb biological potency based on determination of the maximum antagonism rate model. The rhein may be the effective substance. It may serve as a reference in the quality control of wine processed rhubarb products.

rhubarb  /  activate blood and remove stasis  /  biological potency assay  /  fingerprint chromatogram  /  quality evaluation
Hai-zhu ZHANG, Peng TAN, Zhen-jie LIU, Jian WANG, Jia-bo WANG, Xiao-he XIAO. Activating blood biological potency assay and chemical fingerprint chromatogram applied to quality evaluation of rhubarb[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 436 -442 . DOI: 10.16438/j.0513-4870.2016-0896
Appendix
Less
Year 2017 volume 52 Issue 3
PDF
161
66
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2016-0896
  • Receive Date：2016-09-10
  • Online Date：2026-01-14
  • Published：2017-03-12
Article Data
Affiliations
History
  • Received：2016-09-10
  • Revised：2016-10-02
Funding
Affiliations
    1. Department of Pharmacy and Chemistry, Dali University, Dali 671000, China
    2. China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China
    3. Chengdu Institute for Food and Drug Control, Chengdu 610045, China
    4. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2016-0896
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House