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Population pharmacokinetics and its application in new drug research
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Wen-jun CHEN, Tian-yan ZHOU, Wei LU*
Acta Pharmaceutica Sinica | 2017, 52(3) : 371 - 377
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Acta Pharmaceutica Sinica | 2017, 52(3): 371-377
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Population pharmacokinetics and its application in new drug research
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Wen-jun CHEN, Tian-yan ZHOU, Wei LU*
Affiliations
  • School of Pharmaceutical Science, Peking University, Beijing 100191, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-0907
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Population pharmacokinetics is an emerging discipline developed from the combination of classical pharmacokinetic compartment model and statistics principles, which has been received more and more attention in recent years. Population pharmacokinetics plays important roles in all stages of new drug research. In the early preclinical phase, population pharmacokinetic analysis can help to achieve the preliminary prediction of parameters from animal to human, optimize clinical trial designs, and shorten the time required for new drugs from laboratory to clinical trials. In clinical trials and applications stage, population pharmacokinetic research can help researchers investigate the related covariates that affecting pharmacokinetic behavior of patients comprehensively, and find potential drug-drug interactions in clinical. In addition, population pharmacokinetics has a unique advantage in pediatric drug development due to its strong analysis ability of sparse data. This paper provides a summary on the history and methods of population pharmacokinetics, and the application in new drug discovery and development.

population pharmacokinetics  /  new drug research  /  drug-drug interaction  /  pediatric drug use
Wen-jun CHEN, Tian-yan ZHOU, Wei LU. Population pharmacokinetics and its application in new drug research[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 371 -377 . DOI: 10.16438/j.0513-4870.2016-0907
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doi: 10.16438/j.0513-4870.2016-0907
  • Receive Date：2016-09-15
  • Online Date：2026-01-14
  • Published：2017-03-12
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  • Received：2016-09-15
  • Revised：2016-10-10
Affiliations
    School of Pharmaceutical Science, Peking University, Beijing 100191, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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