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Protective effect and underlying mechanism of cordycepin on non-alcoholic fatty liver in ob/ob mice
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Li-ping ZHONG1, Jin LI2, Feng-zhong WANG2, Hai-bo ZHU3, Xu-jie HOU1, *
Acta Pharmaceutica Sinica | 2017, 52(1) : 106 - 112
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Acta Pharmaceutica Sinica | 2017, 52(1): 106-112
• ORIGINAL ARTICLES •
Protective effect and underlying mechanism of cordycepin on non-alcoholic fatty liver in ob/ob mice
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Li-ping ZHONG1, Jin LI2, Feng-zhong WANG2, Hai-bo ZHU3, Xu-jie HOU1, *
Affiliations
  • 1. Xinjiang Production & Construction Corps Key Laboratory of Deep Processing of Agricultural Products in South Xinjiang, College of Life Science, Tarim University, Alar 843300, China
  • 2. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China
  • 3. State Key Laboratory for Bioactive Substances and Functions of Natural Medicines;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-01-12 doi: 10.16438/j.0513-4870.2016-0886
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This study is designed to investigate the protective effect and mechanism of cordycepin on nonalcoholic fatty liver in ob/ob mice. Twelve-week-old male ob/ob mice were divided into 5 groups according to their body weight and blood glucose, and C57BL/6J mice were used in the control group. The animals were orally administered with cordycepin for 7 weeks. Body weight and food intake were measured once a week. Blood were collected from ophthalmic venous and biochemical indexes were determined at the 2nd and 4th week. Insulin tolerance test was performed at the 5th week. After 7 weeks of administration, liver tissues were collected to determine the contents of triglycerides and total cholesterol, and pro-inflammatory cytokines. Liver histology was performed by hematoxylin-eosin and oil-red O staining. Total RNA were extracted from liver tissues and the levels of lipid metabolism-related and inflammation-related genes were detected by real time PCR. Cordycepin effectively reduced the blood lipids level and improved liver function. Nevertheless, it did not improve insulin resistance in ob/ob mice. Cordycepin significantly reduced the contents of triglycerides and cholesterol, and the levels of pro-inflammatory cytokines in liver tissues. Moreover, cordycepin remarkably suppressed the expression of genes related to lipids synthesis and inflammation. These results indicate that cordycepin may improve non-alcoholic fatty liver in ob/ob mice, and the underlying mechanism may be associated with decreased expression of genes related to lipids synthesis and inflammation.

non-alcoholic fatty liver disease  /  cordycepin  /  ob/ob mice  /  lipids synthesis  /  inflammatory cytokines
Li-ping ZHONG, Jin LI, Feng-zhong WANG, Hai-bo ZHU, Xu-jie HOU. Protective effect and underlying mechanism of cordycepin on non-alcoholic fatty liver in ob/ob mice[J]. Acta Pharmaceutica Sinica, 2017 , 52 (1) : 106 -112 . DOI: 10.16438/j.0513-4870.2016-0886
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Article Info
doi: 10.16438/j.0513-4870.2016-0886
  • Receive Date：2016-09-07
  • Online Date：2026-01-14
  • Published：2017-01-12
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History
  • Received：2016-09-07
  • Revised：2016-10-24
Funding
Affiliations
    1. Xinjiang Production & Construction Corps Key Laboratory of Deep Processing of Agricultural Products in South Xinjiang, College of Life Science, Tarim University, Alar 843300, China
    2. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    3. State Key Laboratory for Bioactive Substances and Functions of Natural Medicines;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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