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Advances in the research of inhibitors of enzymes of bacterial peptidoglycan biosynthesis
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Fan LIU1, Hao-yi MENG1, Zheng-yang SUN1, Dan-yang LI2, Yuan-yuan JIN2, Zhao-yong YANG2, Shao-jie WU3, *, Jing CHEN1, *
Acta Pharmaceutica Sinica | 2017, 52(3) : 362 - 370
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Acta Pharmaceutica Sinica | 2017, 52(3): 362-370
• REVIEWS •
Advances in the research of inhibitors of enzymes of bacterial peptidoglycan biosynthesis
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Fan LIU1, Hao-yi MENG1, Zheng-yang SUN1, Dan-yang LI2, Yuan-yuan JIN2, Zhao-yong YANG2, Shao-jie WU3, *, Jing CHEN1, *
Affiliations
  • 1. School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063000, China
  • 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 3. HuaiHai Insititute of Technology, Lianyungang 222000, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-0902
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In recent years, owing to the abuse of antibiotics, the widespread of resistant bacterial strains became a serious threat to public health. This status demands development of new antibacterial agents with novel mechanisms of action. The reason for the limited new antibacterials is the small number of effective therapeutic targets, which cannot meet the current needs for the multiple drug-resistant treatment. Screening for new targets is the key step in the development of novel antibacterial agents. Peptidoglycan is the main component of the cell wall of bacteria, which is essential for survival of pathogenic bacteria. Within the biochemical pathway for peptidoglycan biosynthes is the Murligases, described in this review as highly potential targets for the development of new classes of antibacterial agents. This review provides an in-depth insight into the recent developments in the field of inhibitors of the Mur enzymes (MurA-F). Moreover, the reasons for the lack of candidate inhibitors and the challenges to overcome the hurdles are also discussed.

peptidoglycan  /  antibiotics  /  Mur enzyme  /  enzyme inhibitor  /  drug discovery
Fan LIU, Hao-yi MENG, Zheng-yang SUN, Dan-yang LI, Yuan-yuan JIN, Zhao-yong YANG, Shao-jie WU, Jing CHEN. Advances in the research of inhibitors of enzymes of bacterial peptidoglycan biosynthesis[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 362 -370 . DOI: 10.16438/j.0513-4870.2016-0902
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Year 2017 volume 52 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2016-0902
  • Receive Date：2016-09-18
  • Online Date：2026-01-14
  • Published：2017-03-12
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History
  • Received：2016-09-18
  • Revised：2016-10-12
Funding
Affiliations
    1. School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063000, China
    2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    3. HuaiHai Insititute of Technology, Lianyungang 222000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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