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Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke
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Ying PENG1, Fei MA1, Ting-ting XU1, Shan WANG1, Long-jian HUANG1, Xiao-ying WANG2, *, Yong-jun WANG3, *, Xiao-liang WANG1, *
Acta Pharmaceutica Sinica | 2017, 52(3) : 339 - 346
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Acta Pharmaceutica Sinica | 2017, 52(3): 339-346
• PROFESSIONALS FORUM •
Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke
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Ying PENG1, Fei MA1, Ting-ting XU1, Shan WANG1, Long-jian HUANG1, Xiao-ying WANG2, *, Yong-jun WANG3, *, Xiao-liang WANG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
  • 3. Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-1018
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Translating of scientific advances into clinical practice is a major challenge in the stroke research field in the past decades. There were many reasons involved:animal models might not accurately capture all aspects of clinical stroke in humans, the blind and randomized design principle was not closely followed, the inclusion and exclusion criteria was not previously established, sample size was inadequate, endpoint was not scientific nor blindly assessed, inadequate reporting of data and statistical flaws. To bridge the gap between experimental and clinical research, international consortia have attempted to establish standardized guidelines for study design and data report, which include optimizing animal models as well as experimental design, using innovative approaches to assess endpoint, making raw data and negative results available, establishing prior registration mechanism, conducting multicenter preclinical randomized controlled trials (pRCTs), systematic reviews and meta-analysis of preclinical studies, evolving the original focus on neuroprotection into a broader consideration of the role of neurovascular unit and ischemic cascade.

ischemic stroke  /  therapeutic drug  /  preclinical research  /  clinical translation
Ying PENG, Fei MA, Ting-ting XU, Shan WANG, Long-jian HUANG, Xiao-ying WANG, Yong-jun WANG, Xiao-liang WANG. Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 339 -346 . DOI: 10.16438/j.0513-4870.2016-1018
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Article Info
doi: 10.16438/j.0513-4870.2016-1018
  • Receive Date：2016-10-19
  • Online Date：2026-01-14
  • Published：2017-03-12
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  • Received：2016-10-19
  • Revised：2016-11-25
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Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    3. Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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