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Induction study of CYP3A2 in male rats by zolmitriptan
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Kun HAN, Si-jie LU, Su ZENG, Lu-shan YU*
Acta Pharmaceutica Sinica | 2017, 52(1) : 44 - 50
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Acta Pharmaceutica Sinica | 2017, 52(1): 44-50
• SPECIAL REPORTS •
Induction study of CYP3A2 in male rats by zolmitriptan
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Kun HAN, Si-jie LU, Su ZENG, Lu-shan YU*
Affiliations
  • Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Published: 2017-01-12 doi: 10.16438/j.0513-4870.2016-1007
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In our preliminary studies, we observed zolmitriptan (ZOL) treatment led to induction of CYP3A2 in male not female rats. To figure out the reason is of great significance for drug-drug interactions and personalized administration. Since growth hormone (GH) is known as the major mechanistic determinant of sexually-dimorphic gene expression like CYP3A2 in rat liver, the impacts of ZOL on both plasma GH levels in non monosodium glutamate (MSG)-treated rats and CYP3A2 expression in GH depleted MSG-treated rats were studied. ZOL was shown to partially suppress GH levels in both genders. Furthermore, CYP3A2 protein and mRNA level declined in male not female MSG-treated rats. In order to study the possible molecular events involved in the depression of GH and gender-selective induction on rat CYP3A2 by ZOL, the mRNA and protein level (whole protein and nuclear protein) of hepatocyte nuclear factor 4α (HNF4α) was investigated. Nuclear accumulation of HNF4α was observed in the normal male not female rat liver tissue following ZOL treatment. However, this kind of nuclear translocation did not occur in rat hepatocytes and MSG-treated rats. These findings demonstrated CYP3A2 inducibility by ZOL was gender-selective. GH and HNF4α may play an important role in CYP3A2 induction.

zolmitriptan  /  CYP3A2  /  gender-dependent induction  /  growth hormone  /  hepatocyte nuclear factor 4α
Kun HAN, Si-jie LU, Su ZENG, Lu-shan YU. Induction study of CYP3A2 in male rats by zolmitriptan[J]. Acta Pharmaceutica Sinica, 2017 , 52 (1) : 44 -50 . DOI: 10.16438/j.0513-4870.2016-1007
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doi: 10.16438/j.0513-4870.2016-1007
  • Receive Date：2016-10-17
  • Online Date：2026-01-14
  • Published：2017-01-12
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  • Received：2016-10-17
  • Revised：2016-11-28
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    Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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