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Advances in the study of the rat model of aging induced by D-galactose
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Fan-fan ZHAO1, 2, Yu-zhi ZHOU1, *, Li GAO1, Xue-mei QIN1, Guan-hua DU1, 3, *
Acta Pharmaceutica Sinica | 2017, 52(3) : 347 - 354
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Acta Pharmaceutica Sinica | 2017, 52(3): 347-354
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Advances in the study of the rat model of aging induced by D-galactose
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Fan-fan ZHAO1, 2, Yu-zhi ZHOU1, *, Li GAO1, Xue-mei QIN1, Guan-hua DU1, 3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-0696
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D-galactose (D-gal)-induced aging model is widely used in the study of the pharmacodynamics of antiaging drugs. The model has a shorter life-span, disorders in learning and memory, reduced immune function and other aging characteristics. Regular and quantitative injection of D-gal solution to rats can produce symptoms of natural aging models that are used in screening of antiaging drugs, and their pharmacological activities. This paper provides a summary of the mechanism of rat model induced with D-gal solution. The methods of building and evaluation of the aging models are provided. The theoretical basis is included to facilitate the subsequent research and experiment in the mechanism study of aging and antiaging medicines.

D-galactose  /  aging model  /  rat  /  model establishment method  /  model evaluation  /  metabonomics
Fan-fan ZHAO, Yu-zhi ZHOU, Li GAO, Xue-mei QIN, Guan-hua DU. Advances in the study of the rat model of aging induced by D-galactose[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 347 -354 . DOI: 10.16438/j.0513-4870.2016-0696
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Article Info
doi: 10.16438/j.0513-4870.2016-0696
  • Receive Date：2016-08-10
  • Online Date：2026-01-14
  • Published：2017-03-12
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History
  • Received：2016-08-10
  • Revised：2016-09-30
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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