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Advances in studies of ileal apical sodium-dependent bile acid transporter
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Mao-xu GE, Ju-xian WANG, Rong-guang SHAO, Hong-wei HE*
Acta Pharmaceutica Sinica | 2017, 52(2) : 189 - 197
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Acta Pharmaceutica Sinica | 2017, 52(2): 189-197
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Advances in studies of ileal apical sodium-dependent bile acid transporter
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Mao-xu GE, Ju-xian WANG, Rong-guang SHAO, Hong-wei HE*
Affiliations
  • Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-02-12 doi: 10.16438/j.0513-4870.2016-0654
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Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal apical sodium-dependent bile acid transporter (ASBT) located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently, a number of investigations have been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal inflammation, tumorigenesis, diabetes mellitus and hyperlipemia, which suggests ASBT as a potential therapeutic target of these diseases. In this review, advances in the study of above-mentioned issues were summarized.

bile acid  /  apical sodium-dependent bile acid transporter  /  intestinal tract tumor  /  hyperlipemia  /  diabetes mellitus
Mao-xu GE, Ju-xian WANG, Rong-guang SHAO, Hong-wei HE. Advances in studies of ileal apical sodium-dependent bile acid transporter[J]. Acta Pharmaceutica Sinica, 2017 , 52 (2) : 189 -197 . DOI: 10.16438/j.0513-4870.2016-0654
Year 2017 volume 52 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2016-0654
  • Receive Date:2016-07-01
  • Online Date:2026-01-14
  • Published:2017-02-12
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  • Received:2016-07-01
  • Revised:2016-07-24
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    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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