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Investigation of the potentially effective components of Semen Ziziphi Spinosae based on "in vitro to in vivo" translation approach
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Yan YAN1, *, Qiang LI1, 2, Chen-hui DU3, Jin-ping JIA4, Hong-xia FENG3, Xue-mei QIN1, *
Acta Pharmaceutica Sinica | 2017, 52(2) : 283 - 290
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Acta Pharmaceutica Sinica | 2017, 52(2): 283-290
• Pharmaceutical Analysis •
Investigation of the potentially effective components of Semen Ziziphi Spinosae based on "in vitro to in vivo" translation approach
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Yan YAN1, *, Qiang LI1, 2, Chen-hui DU3, Jin-ping JIA4, Hong-xia FENG3, Xue-mei QIN1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. College of Chinese Materia Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
  • 4. Scientific Instrument Center, Shanxi University, Taiyuan 030006, China
Published: 2017-02-12 doi: 10.16438/j.0513-4870.2016-0644
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The study aims to investigate the effective components of Semen Ziziphi Spinosae (SZR) in nourishing the heart and tranquilizing the mind. A method of ultra high liquid chromatography (UHPLC) coupled with Q Exactive high resolution mass spectrometry (HR-MS) was developed. Based on the UV spectra, retention time and MS spectra, 25 compounds of SZR extract were identified or tentatively characterized, including 12 flavonoids, 8 triterpenoids saponins, 2 fatty acid and 3 alakoids. The study illuminated the major chemical components. Twenty bioactive components were determined in rat urine after oral administration of SZR extract by "in vitro to in vivo" translation approach, including 16 prototype compounds and 4 metabolites. Spinosin, swertisin, jujuboside A and B were considered as the effective and active constituents in SZR of the sedative and hypnotic effects, which emodies characteristics of multiple components. It was beneficial exploration for searching the effective and active constituents of SZR in nourishing the heart and tranquilizing the mind.

Semen Ziziphi Spinosae  /  "in vitro to in vivo" translation approach  /  high resolution mass spectrometry  /  effective and active constituent
Yan YAN, Qiang LI, Chen-hui DU, Jin-ping JIA, Hong-xia FENG, Xue-mei QIN. Investigation of the potentially effective components of Semen Ziziphi Spinosae based on "in vitro to in vivo" translation approach[J]. Acta Pharmaceutica Sinica, 2017 , 52 (2) : 283 -290 . DOI: 10.16438/j.0513-4870.2016-0644
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Article Info
doi: 10.16438/j.0513-4870.2016-0644
  • Receive Date：2016-06-29
  • Online Date：2026-01-14
  • Published：2017-02-12
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History
  • Received：2016-06-29
  • Revised：2016-09-19
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. College of Chinese Materia Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
    4. Scientific Instrument Center, Shanxi University, Taiyuan 030006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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