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Research progress of human cytochrome P450 2J2 and its ligands
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Hong-ying MA1, 2, Jing NING2, Guang-bo GE2, *, Ling YANG2, Da-cheng HAO1, *
Acta Pharmaceutica Sinica | 2017, 52(1) : 26 - 33
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Acta Pharmaceutica Sinica | 2017, 52(1): 26-33
• SPECIAL REPORTS •
Research progress of human cytochrome P450 2J2 and its ligands
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Hong-ying MA1, 2, Jing NING2, Guang-bo GE2, *, Ling YANG2, Da-cheng HAO1, *
Affiliations
  • 1. School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China
  • 2. Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Published: 2017-01-12 doi: 10.16438/j.0513-4870.2016-0573
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Cytochrome P4502J2 (CYP2J2) is widely distributed in various human tissues and takes a part in the metabolism of endogenous compounds and drugs. CYP2J2 can convert arachidonic acid (AA) to expoxyeicosatrienoic acids (EETs), which have various biological effects, implying the important role of CYP2J2 in the regulation of cardiovascular system and promotion of tumor progression and metastasis. Additionally, CYP2J2 plays an indispensable role in the intestinal metabolism of various drugs, such as astemizole, terfenadine and ebastine. In this review, the metabolic function, characteristic of catalysis and tissue distribution of CYP2J2 are discussed with the latest literatures both in China and abroad. The state-of-the-art methods for characterization of CYP2J2 and current trend of substrate discovery as well as its relationship with disease are highlighted. This review gives in-depth understanding of the function of CYP2J2 and its role in disease advance. The information of ligand (substrate and inhibitor) will provide the theoretical guidance and reference to the development of novel drugs for CYP2J2.

CYP2J2  /  metabolism  /  human disease  /  probe substrate  /  CYP2J2 inhibitor
Hong-ying MA, Jing NING, Guang-bo GE, Ling YANG, Da-cheng HAO. Research progress of human cytochrome P450 2J2 and its ligands[J]. Acta Pharmaceutica Sinica, 2017 , 52 (1) : 26 -33 . DOI: 10.16438/j.0513-4870.2016-0573
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Article Info
doi: 10.16438/j.0513-4870.2016-0573
  • Receive Date：2016-06-15
  • Online Date：2026-01-14
  • Published：2017-01-12
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History
  • Received：2016-06-15
  • Revised：2016-07-19
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Affiliations
    1. School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China
    2. Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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