Home Journals Articles Updates About
CN
image
收藏切换
Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity
收藏切换
Meng YANG1, 2, Zhi-you HAO1, 2, Shi-qi ZHOU1, 2, Bing CAO1, 2, Deng-hui ZHU1, 2, Ying YANG1, 2, Jun-jun WEI1, 2, Si-qi TAO1, 2, Bo-wen ZHANG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(12) : 3608 - 3615
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(12): 3608-3615
• Original Articles •
Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity
Full
Meng YANG1, 2, Zhi-you HAO1, 2, Shi-qi ZHOU1, 2, Bing CAO1, 2, Deng-hui ZHU1, 2, Ying YANG1, 2, Jun-jun WEI1, 2, Si-qi TAO1, 2, Bo-wen ZHANG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2022-12-12 doi: 10.16438/j.0513-4870.2022-0853
Outline
收藏切换

Fifteen compounds were isolated from fruits of Cornus officinalis by various chromatographic techniques such as Toyopearl HW-40C, Sephadex LH-20, silica gel, and the semi-preparative HPLC. Their chemical structures were identified by analysis of physicochemical properties and spectral data, and determined as neolignan A (1), caffeic acid (2), trans-p-hydroxy cinnamic acid (3), esculetin (4), scopoletin (5), benzyl-7-O-β-D-glucopyranoside (6), tachioside (7), 6-O-(4-hydroxybenzoyl) arbutin (8), 2-(3′, 4′-dihydroxyphenyl)-1, 3-benzodioxole-5-carboxaldehyde (9), (-)-pinoresinol-4-O-β-D-glucopyranoside (10), (7S, 8R)-dihydrodehydrodiconiferyl alcohol-9-O-β-D-glucopyranoside (11), (7S, 8R)-dihydrodehydrodiconiferyl alcohol-9′-O-β-D-glucopyranoside (12), (+)-lyoniresinol (13), (+)-isolariciresinol-9-O-β-D-glucopyranoside (14), and isolariciresinol-9′-O-β-D-glucopyranoside (15). Compound 1 was a new compound and named as neolignan A, and compounds 6-9 and 14 were isolated from Cornus officinalis for the first time. Compounds 2, 3 and 15 efficiently alleviated the PC12 cells injury induced by Aβ25-35, suggesting their potential anti-Alzheimer's disease activity.

Cornus officinalis  /  chemical constituent  /  lignan glycoside  /  neolignan A  /  anti-Alzheimer's disease activity
杨梦, 郝志友, 周诗琪, 曹兵, 朱登辉, 杨颖, 魏俊俊, 陶思琦, 张博文, 郑晓珂, 冯卫生. 山茱萸果实化学成分及其抗阿尔茨海默症活性研究. 药学学报, 2022 , 57 (12) : 3608 -3615 . DOI: 10.16438/j.0513-4870.2022-0853
Meng YANG, Zhi-you HAO, Shi-qi ZHOU, Bing CAO, Deng-hui ZHU, Ying YANG, Jun-jun WEI, Si-qi TAO, Bo-wen ZHANG, Xiao-ke ZHENG, Wei-sheng FENG. Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity[J]. Acta Pharmaceutica Sinica, 2022 , 57 (12) : 3608 -3615 . DOI: 10.16438/j.0513-4870.2022-0853
Appendix
Less
Year 2022 volume 57 Issue 12
892
559
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0853
  • Receive Date：2022-07-11
  • Online Date：2025-12-24
  • Published：2022-12-12
Article Data
Affiliations
History
  • Received：2022-07-11
  • Revised：2022-10-07
Funding
Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0853
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House