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Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity
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Meng YANG1, 2, Zhi-you HAO1, 2, Shi-qi ZHOU1, 2, Bing CAO1, 2, Deng-hui ZHU1, 2, Ying YANG1, 2, Jun-jun WEI1, 2, Si-qi TAO1, 2, Bo-wen ZHANG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(12) : 3608 - 3615
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Acta Pharmaceutica Sinica | 2022, 57(12): 3608-3615
• Original Articles •
Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity
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Meng YANG1, 2, Zhi-you HAO1, 2, Shi-qi ZHOU1, 2, Bing CAO1, 2, Deng-hui ZHU1, 2, Ying YANG1, 2, Jun-jun WEI1, 2, Si-qi TAO1, 2, Bo-wen ZHANG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2022-12-12 doi: 10.16438/j.0513-4870.2022-0853
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Fifteen compounds were isolated from fruits of Cornus officinalis by various chromatographic techniques such as Toyopearl HW-40C, Sephadex LH-20, silica gel, and the semi-preparative HPLC. Their chemical structures were identified by analysis of physicochemical properties and spectral data, and determined as neolignan A (1), caffeic acid (2), trans-p-hydroxy cinnamic acid (3), esculetin (4), scopoletin (5), benzyl-7-O-β-D-glucopyranoside (6), tachioside (7), 6-O-(4-hydroxybenzoyl) arbutin (8), 2-(3′, 4′-dihydroxyphenyl)-1, 3-benzodioxole-5-carboxaldehyde (9), (-)-pinoresinol-4-O-β-D-glucopyranoside (10), (7S, 8R)-dihydrodehydrodiconiferyl alcohol-9-O-β-D-glucopyranoside (11), (7S, 8R)-dihydrodehydrodiconiferyl alcohol-9′-O-β-D-glucopyranoside (12), (+)-lyoniresinol (13), (+)-isolariciresinol-9-O-β-D-glucopyranoside (14), and isolariciresinol-9′-O-β-D-glucopyranoside (15). Compound 1 was a new compound and named as neolignan A, and compounds 6-9 and 14 were isolated from Cornus officinalis for the first time. Compounds 2, 3 and 15 efficiently alleviated the PC12 cells injury induced by Aβ25-35, suggesting their potential anti-Alzheimer's disease activity.

Cornus officinalis  /  chemical constituent  /  lignan glycoside  /  neolignan A  /  anti-Alzheimer's disease activity
Meng YANG, Zhi-you HAO, Shi-qi ZHOU, Bing CAO, Deng-hui ZHU, Ying YANG, Jun-jun WEI, Si-qi TAO, Bo-wen ZHANG, Xiao-ke ZHENG, Wei-sheng FENG. Chemical constituents from fruits of Cornus officinalis and their anti-Alzheimer's disease activity[J]. Acta Pharmaceutica Sinica, 2022 , 57 (12) : 3608 -3615 . DOI: 10.16438/j.0513-4870.2022-0853
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Article Info
doi: 10.16438/j.0513-4870.2022-0853
  • Receive Date：2022-07-11
  • Online Date：2025-12-24
  • Published：2022-12-12
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  • Received：2022-07-11
  • Revised：2022-10-07
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Research Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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