Home Journals Articles Updates About
CN
image
收藏切换
A new anisotane-type sesquiterpene from Anisodus tanguticus
收藏切换
PDF
Na ZOU1, 2, Hao-yu ZHAO1, 2, Huan ZHU1, 2, Cheng PENG1, 2, Zhao-hua LIU3, Qin-mei ZHOU1, 2, 4, *, Liang XIONG1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(12) : 3616 - 3620
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(12): 3616-3620
• Original Articles •
A new anisotane-type sesquiterpene from Anisodus tanguticus
Full
Na ZOU1, 2, Hao-yu ZHAO1, 2, Huan ZHU1, 2, Cheng PENG1, 2, Zhao-hua LIU3, Qin-mei ZHOU1, 2, 4, *, Liang XIONG1, 2, *
Affiliations
  • 1. State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2. Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 3. Chengdu No.1 Pharmaceutical Co. Ltd., Chengdu 610031, China
  • 4. Innovation Institute of Chinese Medicine Innovation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Published: 2022-12-12 doi: 10.16438/j.0513-4870.2022-0926
Outline
收藏切换

To investigate the chemical constituents of Anisodus tanguticus, silica gel column chromatography, Sephadex LH-20 column chromatography, preparative thin layer chromatography, and semi-preparative HPLC were used to separate and purify the chemical constituents from the extract of A. tanguticus. The planar structure of the isolated compound was identified by HRMS, IR, and 2D NMR experiments. The absolute configuration of the isolated compound was determined by a combination of NOESY, coupling constant, circular dichroism (CD), and transition metal chelate reagent dimolybdenum tetraacetate [Mo2(OAc)4]-induced circular dichroism (ICD) data analysis. A new compound of the anisotane-type sesquiterpene (1) was isolated, which was determined to be (1R, 2S, 3R, 4R, 6R, 7R, 9R)-anisotane-11(13)-ene-3, 4, 9-triol and named anisotanol F. This is the second report of anisotane-type sesquiterpene, which has previously been reported as a novel sesquiterpenoid skeleton by our research group. Furthermore, the cytotoxicity against HUVECs and inhibitory effect on NO release in LPS-induced RAW264.7 cells of compound 1 were investigated. However, the results showed that it was inactive. Compound 1 is a new compound isolated from A. tanguticus. It belongs to the unusual anisotane-type sesquiterpene. This result enriches the chemical composition of A. tanguticus.

Anisodus tanguticus  /  isolation and identification  /  new compound  /  absolute configuration  /  sesquiterpene
Na ZOU, Hao-yu ZHAO, Huan ZHU, Cheng PENG, Zhao-hua LIU, Qin-mei ZHOU, Liang XIONG. A new anisotane-type sesquiterpene from Anisodus tanguticus[J]. Acta Pharmaceutica Sinica, 2022 , 57 (12) : 3616 -3620 . DOI: 10.16438/j.0513-4870.2022-0926
Appendix
Less
Year 2022 volume 57 Issue 12
PDF
143
48
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0926
  • Receive Date：2022-07-28
  • Online Date：2025-12-24
  • Published：2022-12-12
Article Data
Affiliations
History
  • Received：2022-07-28
  • Revised：2022-09-30
Funding
Affiliations
    1. State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2. Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    3. Chengdu No.1 Pharmaceutical Co. Ltd., Chengdu 610031, China
    4. Innovation Institute of Chinese Medicine Innovation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0926
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House