Home Journals Articles Updates About
CN
image
收藏切换
Investigation of metabolites of synthetic cannabinoid 4CN-MDMB-BUTINAC in vitro by liquid-chromatography-quadruple/orbitrap mass spectrometry
收藏切换
PDF
Shan-hui ZHOU1, Yu XU2, Zhen-feng YU1, Xing KE1, Yi-lei FAN1, *
Acta Pharmaceutica Sinica | 2022, 57(12) : 3653 - 3659
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(12): 3653-3659
• Original Articles •
Investigation of metabolites of synthetic cannabinoid 4CN-MDMB-BUTINAC in vitro by liquid-chromatography-quadruple/orbitrap mass spectrometry
Full
Shan-hui ZHOU1, Yu XU2, Zhen-feng YU1, Xing KE1, Yi-lei FAN1, *
Affiliations
  • 1. Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China
  • 2. Key Laboratory of Drug Monitoring and Control of Zhejiang Province, National Anti-Drug Laboratory Zhejiang Regional Center, Hangzhou 310053, China
Published: 2022-12-12 doi: 10.16438/j.0513-4870.2022-0924
Outline
收藏切换

To investigate the metabolites of a new synthetic cannabinoid 3, 3-dimethyl-2-[1-(4-cyanobutyl)indazole-3-formamimino]methyl butyrate (4CN-MDMB-BUTINACA) in vitro, a human liver microsome incubation model was established to analyze the metabolic biotransformation of synthetic cannabinoids using ultra-high performance liquid chromatography coupled to quadrupole-orbitrap high-resolution mass spectrometry. Nontarget metabolomic results showed that the metabolites of 4CN-MDMB-BUTINACA included hydroxylation, ester hydrolysis, ester hydrolysis with hydroxylation reaction, pentane oxidation and ester hydrolysis with pentane oxidation reaction, among which M1-a, M2 and M4 were potential metabolic markers. The research results provide a theoretical basis and technical support for the biomonitoring and metabolic characterisation of the cannabinoid 4CN-MDMB-BUTINACA.

synthetic cannabinoid  /  liver microsome  /  metabolite  /  metabolic pathway
Shan-hui ZHOU, Yu XU, Zhen-feng YU, Xing KE, Yi-lei FAN. Investigation of metabolites of synthetic cannabinoid 4CN-MDMB-BUTINAC in vitro by liquid-chromatography-quadruple/orbitrap mass spectrometry[J]. Acta Pharmaceutica Sinica, 2022 , 57 (12) : 3653 -3659 . DOI: 10.16438/j.0513-4870.2022-0924
Appendix
Less
Year 2022 volume 57 Issue 12
PDF
142
53
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0924
  • Receive Date：2022-07-28
  • Online Date：2025-12-24
  • Published：2022-12-12
Article Data
Affiliations
History
  • Received：2022-07-28
  • Revised：2022-09-29
Funding
Affiliations
    1. Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China
    2. Key Laboratory of Drug Monitoring and Control of Zhejiang Province, National Anti-Drug Laboratory Zhejiang Regional Center, Hangzhou 310053, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0924
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House