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Mechanism of Sanzi Yangqin decoction to prevent the development of prehypertension and excessive phlegm-dampness syndrome in rats based on hypothalamic metabonomics
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Xiao-qing GUO1, Shu-min LI2, Han YU2, Jian-qiao YE1, Dong-mei QI3, 4, 5, Hai-qiang JIANG1, 4, 5, Yu-chen QI6, *
Acta Pharmaceutica Sinica | 2022, 57(11) : 3387 - 3395
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Acta Pharmaceutica Sinica | 2022, 57(11): 3387-3395
• Original Articles •
Mechanism of Sanzi Yangqin decoction to prevent the development of prehypertension and excessive phlegm-dampness syndrome in rats based on hypothalamic metabonomics
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Xiao-qing GUO1, Shu-min LI2, Han YU2, Jian-qiao YE1, Dong-mei QI3, 4, 5, Hai-qiang JIANG1, 4, 5, Yu-chen QI6, *
Affiliations
  • 1. Institute of Innovation in Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 2. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 3. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 4. Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Jinan 250355, China
  • 5. Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • 6. Faculty of Health, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
Published: 2022-11-12 doi: 10.16438/j.0513-4870.2022-0732
Outline
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The purpose of this study was to explore the mechanism of Sanzi Yangqin decoction (SYD) from the perspective of hypothalamic metabonomics to prevent the development of prehypertension (PHT) and excessive phlegm-dampness syndrome in rats. WKY rats were randomly divided into a normal group, a model group and a SYD group. The high-fat + high-salt method was used to induce PHT and excessive phlegm-dampness syndrome in the model and SYD rats. Different doses of SYD were used as an intervention over 8 weeks. Food consumption, weight, height, blood lipid and blood pressure were recorded for each group. The results show that, compared with the model group, the diet, weight and blood pressure of rats in SYD group decreased. Metabolites in the hypothalamus which differed in their expression between the three groups were identified and analyzed by LC-MS and the metabolic pathways were then determined. Fourteen metabolites in the hypothalamus were down-regulated and were mainly related to amino acid metabolism, glutathione metabolism, sphingolipid metabolism and glyceride metabolism, suggesting that SYD might alter hypothalamic dietary behavior, thereby affecting amino acid metabolism and energy metabolism. This study was approved by the Animal Ethics Review Committee of Shandong University of Traditional Chinese Medicine (approval number: SDUTCM20211103001).

prehypertension  /  excessive phlegm-dampness syndrome  /  Sanzi Yangqin decoction  /  metabonomics  /  hypothalamic
Xiao-qing GUO, Shu-min LI, Han YU, Jian-qiao YE, Dong-mei QI, Hai-qiang JIANG, Yu-chen QI. Mechanism of Sanzi Yangqin decoction to prevent the development of prehypertension and excessive phlegm-dampness syndrome in rats based on hypothalamic metabonomics[J]. Acta Pharmaceutica Sinica, 2022 , 57 (11) : 3387 -3395 . DOI: 10.16438/j.0513-4870.2022-0732
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Year 2022 volume 57 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2022-0732
  • Receive Date：2022-06-16
  • Online Date：2025-12-24
  • Published：2022-11-12
Article Data
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History
  • Received：2022-06-16
  • Revised：2022-08-23
Funding
Affiliations
    1. Institute of Innovation in Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    2. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    3. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    4. Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Jinan 250355, China
    5. Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    6. Faculty of Health, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0732
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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