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Application of native mass spectrometry in natural product research
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Da-fu ZHU1, 2, Chun-ping TANG2, Jia LIU2, *, Yang YE1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(11) : 3292 - 3300
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Acta Pharmaceutica Sinica | 2022, 57(11): 3292-3300
• Reviews •
Application of native mass spectrometry in natural product research
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Da-fu ZHU1, 2, Chun-ping TANG2, Jia LIU2, *, Yang YE1, 2, *
Affiliations
  • 1. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Published: 2022-11-12 doi: 10.16438/j.0513-4870.2022-0769
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Natural products, rich in sources and diverse in structure, play an important role in drug discovery. It is a hotspot to identify efficiently bioactive components from complex mixtures in the field of natural product research. Traditional research methods, starting from extraction and isolation to structural elucidation, and finally to bioactivity assay, are generally time-consuming, laborious, and untargeted. Therefore, there is an urgent need to develop efficient screening methods for bioactive component discovery. Native mass spectrometry (native MS) is an underutilized method based on the interaction between target and ligand, which can rapidly discover potential active components in complex matrices. Due to the simple operation and the native state of the protein, the method is specific, efficient, and simple. Herein, we give a brief introduction of native MS and then review its recent application in natural product research, with its advantages and limitations, which would provide a reference for researchers in relevant fields.

native MS  /  natural product  /  bio-affinity mass spectrometry  /  high-throughput screening  /  molecular interaction
Da-fu ZHU, Chun-ping TANG, Jia LIU, Yang YE. Application of native mass spectrometry in natural product research[J]. Acta Pharmaceutica Sinica, 2022 , 57 (11) : 3292 -3300 . DOI: 10.16438/j.0513-4870.2022-0769
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Article Info
doi: 10.16438/j.0513-4870.2022-0769
  • Receive Date：2022-06-23
  • Online Date：2025-12-24
  • Published：2022-11-12
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  • Received：2022-06-23
  • Revised：2022-08-05
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Affiliations
    1. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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