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Research progress on the anti-dementia effect of Dipsaci Radix and its active compounds
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Jin-shuai CUI1, yan LIU1, Zi-ying WANG1, *, Gang CHENG1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(10) : 3057 - 3066
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Acta Pharmaceutica Sinica | 2022, 57(10): 3057-3066
• Special Reports Ⅱ: Traditional Chinese Medicine in the Prevention and Treatment of Cardio-cerebrovascular Related Diseases •
Research progress on the anti-dementia effect of Dipsaci Radix and its active compounds
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Jin-shuai CUI1, yan LIU1, Zi-ying WANG1, *, Gang CHENG1, 2, *
Affiliations
  • 1. Interdisciplinary Institute of Individualized Prevention and Treatment of Encephalopathy, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
  • 2. Key Laboratory of Endemic and Minority Diseases of Ministry of Education, Guizhou Medical University, Guiyang 550004, China
Published: 2022-10-12 doi: 10.16438/j.0513-4870.2022-0729
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Dementia is a series of diseases with severe cognitive decline caused by brain diseases, that closely related to kidney deficiency in traditional Chinese medicine, including Alzheimer's disease (AD), dementia caused by cerebral stroke, vascular dementia (VAD) and so on. Dipsaci Radix is the dried root of Dipsacus asper Wall. ex Henry and its curative effects mainly focus on nourishing the liver and kidney, strengthening muscles and bones, as well as dredging blood vessels. The main chemical components of Dipsaci Radix are triterpenoid saponins and iridoid glycosides. In recent years, studies have found that Dipsaci Radix and its active compounds could ameliorate dementia symptoms via multiple targets and molecular mechanisms. In this review, we summarize the recent research progress of Dipsaci Radix in dementia prevention, which will provide reference for further exploration of its mechanism and application in the prevention and treatment of dementia.

Dipsaci Radix  /  dementia  /  Alzheimer's disease  /  cerebral stroke  /  vascular dementia
Jin-shuai CUI, yan LIU, Zi-ying WANG, Gang CHENG. Research progress on the anti-dementia effect of Dipsaci Radix and its active compounds[J]. Acta Pharmaceutica Sinica, 2022 , 57 (10) : 3057 -3066 . DOI: 10.16438/j.0513-4870.2022-0729
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Year 2022 volume 57 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2022-0729
  • Receive Date：2022-06-16
  • Online Date：2025-12-24
  • Published：2022-10-12
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  • Received：2022-06-16
  • Revised：2022-08-23
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Affiliations
    1. Interdisciplinary Institute of Individualized Prevention and Treatment of Encephalopathy, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
    2. Key Laboratory of Endemic and Minority Diseases of Ministry of Education, Guizhou Medical University, Guiyang 550004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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