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Research progress on the pharmacodynamic mechanism of antidepressant compound prescriptions and its flavonoids active ingredients
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Wen-zhi HAO1, Lu WANG1, Jun-qing HUANG1, *, Jia-xu CHEN1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(10) : 3035 - 3046
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Acta Pharmaceutica Sinica | 2022, 57(10): 3035-3046
• Special Reports Ⅱ: Traditional Chinese Medicine in the Prevention and Treatment of Cardio-cerebrovascular Related Diseases •
Research progress on the pharmacodynamic mechanism of antidepressant compound prescriptions and its flavonoids active ingredients
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Wen-zhi HAO1, Lu WANG1, Jun-qing HUANG1, *, Jia-xu CHEN1, 2, *
Affiliations
  • 1. Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
  • 2. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Published: 2022-10-12 doi: 10.16438/j.0513-4870.2022-0717
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Depression is a psychiatric disease characterized by long-lasting low mood, accompanied by symptoms such as cognitive, sleep and social disturbances. In the theory of traditional Chinese medicine, depression is included in the categories of "depression syndrome" and "madness", and the main syndrome type is liver stagnation and spleen deficiency. Xiaoyao san, Sini san and Chaihushugan san are commonly used prescriptions for clinical treatment of depression, and flavonoids are the common active ingredients. Clinical and basic studies have shown that the flavonoids derived from antidepressant compound prescription have pharmacological effects such as anti-inflammatory, antioxidant, neuroprotective, and intestinal flora regulation which could prevent the occurrence and development of depression from different pathways. Based on this, this review focuses on the pathogenesis of depression, summarizes the common flavonoids in antidepressant prescriptions, and summarizes their regulatory mechanisms and effects in order to provide ideas for the prevention and treatment of depression.

depression  /  flavonoid  /  neurotransmitter  /  oxidative stress  /  neuroinflammation
Wen-zhi HAO, Lu WANG, Jun-qing HUANG, Jia-xu CHEN. Research progress on the pharmacodynamic mechanism of antidepressant compound prescriptions and its flavonoids active ingredients[J]. Acta Pharmaceutica Sinica, 2022 , 57 (10) : 3035 -3046 . DOI: 10.16438/j.0513-4870.2022-0717
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Article Info
doi: 10.16438/j.0513-4870.2022-0717
  • Receive Date：2022-06-10
  • Online Date：2025-12-24
  • Published：2022-10-12
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  • Received：2022-06-10
  • Revised：2022-07-11
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Affiliations
    1. Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
    2. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
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表12种不同金属材料的力学参数
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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