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Progress on research and development of drug for chronic kidney disease and related comorbidities
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Yi-ge YANG1, 2, He LI1, Xiu-li ZHANG1, Xiao-chuan TAN1, Yu-jia ZHANG1, Wen-sheng ZHENG1, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2682 - 2695
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Acta Pharmaceutica Sinica | 2022, 57(9): 2682-2695
• Reviews •
Progress on research and development of drug for chronic kidney disease and related comorbidities
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Yi-ge YANG1, 2, He LI1, Xiu-li ZHANG1, Xiao-chuan TAN1, Yu-jia ZHANG1, Wen-sheng ZHENG1, *
Affiliations
  • 1. Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Tianjin University, Tianjin 100072, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0134
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Chronic kidney disease (CKD) is a progressive disease with many complications (eg, cardiovascular disease and acidosis and anemia) and high morbidity and mortality occurs in the population. There is no cure for this disease, current treatments including renin-angiotensin-aldosterone pathway inhibitors and sodium-glucose co-transporter 2 inhibitors can only delay the progression to end-stage renal disease. With the identification of more key factors and mechanisms in CKD development, new potential therapeutic approaches for CKD can be developed. This review summarizes the mainstays of therapy and strategies for CKD and related comorbidities to support the development of novel treatments.

chronic kidney disease  /  comorbidity  /  drug development  /  end-stage renal disease  /  clinical trial drug
Yi-ge YANG, He LI, Xiu-li ZHANG, Xiao-chuan TAN, Yu-jia ZHANG, Wen-sheng ZHENG. Progress on research and development of drug for chronic kidney disease and related comorbidities[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2682 -2695 . DOI: 10.16438/j.0513-4870.2022-0134
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Year 2022 volume 57 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2022-0134
  • Receive Date：2022-01-27
  • Online Date：2025-12-24
  • Published：2022-09-12
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History
  • Received：2022-01-27
  • Revised：2022-03-26
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Affiliations
    1. Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Tianjin University, Tianjin 100072, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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