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A new pair of coumarin-like enantiomeric isomers from Gerbera piloselloides
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Ha GAO1, 2, Chen-xu ZHAO1, 2, Xin-yao LUO2, 3, Jing-rong LI2, 4, Yan-jun SUN1, Tao ZHANG2, *, Zhong-mei ZOU1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2774 - 2779
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Acta Pharmaceutica Sinica | 2022, 57(9): 2774-2779
Original Articles
A new pair of coumarin-like enantiomeric isomers from Gerbera piloselloides
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Ha GAO1, 2, Chen-xu ZHAO1, 2, Xin-yao LUO2, 3, Jing-rong LI2, 4, Yan-jun SUN1, Tao ZHANG2, *, Zhong-mei ZOU1, 2, *
Affiliations
  • 1. Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100193, China
  • 3. Pharmacy Faculty Hubei University of Chinese Medicine, Hubei Provincial Key Laboratory of Chinese Medicine Resource, Wuhan 430065, China
  • 4. Guizhou Medical University, Guizhou 550000, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0407
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Ten compounds were isolated from the 95% ethanol extract of the whole plant of Gerbera piloselloides by silica gel column chromatography, MCI column chromatography and semi-preparative HPLC methods. Their structures were identified on the basis of physicochemical properties, spectral data (UV, IR, MS and NMR), circular dichroism (CD) spectra and single crystal X-ray diffraction analysis as 3′R-gerpilosecoumarin A (1a), 3′S-gerpilosecoumarin A (1b), gymnastone (2), gerberinside (3), divaricataester C (4), luteolin (5), caffeic acid methyl ester (6), ethyl chlorogenate (7), 6-(β-D-glucopyranosyloxy)-7-methoxy-5-benzoranpropanoic acid methyl ester (8) and glucozaluzanin C (9). Among them, new compounds 1a and 1b were new compounds and optical enantiomers, which were obtained by chiral resolution, and their absolute configurations were determined by quantum chemical calculation ECD. Compounds 1 and 1a/1b significantly increased the survival of IEC-6 in rat small intestinal crypt epithelial cells after LPS injury.

compositae  /  Gerbera piloselloides  /  X-ray  /  enantiomer  /  survival rate
Ha GAO, Chen-xu ZHAO, Xin-yao LUO, Jing-rong LI, Yan-jun SUN, Tao ZHANG, Zhong-mei ZOU. A new pair of coumarin-like enantiomeric isomers from Gerbera piloselloides[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2774 -2779 . DOI: 10.16438/j.0513-4870.2022-0407
Year 2022 volume 57 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2022-0407
  • Receive Date:2022-04-08
  • Online Date:2025-12-24
  • Published:2022-09-12
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History
  • Received:2022-04-08
  • Revised:2022-04-19
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Affiliations
    1. Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100193, China
    3. Pharmacy Faculty Hubei University of Chinese Medicine, Hubei Provincial Key Laboratory of Chinese Medicine Resource, Wuhan 430065, China
    4. Guizhou Medical University, Guizhou 550000, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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