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Research progress of metabolic flux analysis technology in glucose metabolism pathway research
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Yun-hao ZHAO1, Ting LINGHU1, Wen-ze WU1, Xian-xian WANG1, Yu-mei HAN2, Xue-mei QIN1, *, Jun-sheng TIAN1, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2731 - 2737
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Acta Pharmaceutica Sinica | 2022, 57(9): 2731-2737
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Research progress of metabolic flux analysis technology in glucose metabolism pathway research
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Yun-hao ZHAO1, Ting LINGHU1, Wen-ze WU1, Xian-xian WANG1, Yu-mei HAN2, Xue-mei QIN1, *, Jun-sheng TIAN1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. School of Physical Education, Shanxi University, Taiyuan 030006, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0311
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With the wide application of stable isotope tracer metabolomics technology, its comprehensive analysis and in-depth mining of data are particularly important, and metabolic flux analysis is one of the main technical means, especially in the study of glucose metabolism. Metabolic flux analysis technology combines isotope tracing with mathematical models to deduce and calculate the metabolic flux between metabolites. The metabolic flux provides more information for research and reflects a dynamic metabolic process more clearly and specifically. This paper reviews the basic process, precautions, and application examples of metabolic flux analysis in glucose metabolism research, and provides a reference for the application of metabolic flux analysis based on stable isotope tracer metabolomics in glucose metabolism research.

metabolic flux analysis  /  stable isotope tracer metabolomics  /  glucose metabolism  /  metabolic pathway
Yun-hao ZHAO, Ting LINGHU, Wen-ze WU, Xian-xian WANG, Yu-mei HAN, Xue-mei QIN, Jun-sheng TIAN. Research progress of metabolic flux analysis technology in glucose metabolism pathway research[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2731 -2737 . DOI: 10.16438/j.0513-4870.2022-0311
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Article Info
doi: 10.16438/j.0513-4870.2022-0311
  • Receive Date：2022-03-11
  • Online Date：2025-12-24
  • Published：2022-09-12
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History
  • Received：2022-03-11
  • Revised：2022-06-29
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    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. School of Physical Education, Shanxi University, Taiyuan 030006, China
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