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Research progresses on NLRP3 inflammasomes-induced anti-tumor immunity
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Cui-cui SUN, Jing-wen DONG, Ze-an KUANG, Ming-xiao YIN, Xiao-jia LIU, Hong-bin DENG*
Acta Pharmaceutica Sinica | 2022, 57(9) : 2612 - 2621
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Acta Pharmaceutica Sinica | 2022, 57(9): 2612-2621
• Special Reports: Therapeutic interventions and strategies for cancer immunotherapy •
Research progresses on NLRP3 inflammasomes-induced anti-tumor immunity
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Cui-cui SUN, Jing-wen DONG, Ze-an KUANG, Ming-xiao YIN, Xiao-jia LIU, Hong-bin DENG*
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  • Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0520
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More and more studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome has become the regulatory factor of inflammatory response and protective immunity, and the assembly and activation of NLRP3 inflammasomes are closely related to the anti-tumor immunity effect. Depending on the cell type and stimuli, activation of the NLRP3 inflammasome can induce immune cells to become polarized, hyperactive, or pyroptotic, releasing interleukin (IL)-1β and IL-18, which leads to cascade immune or inflammatory responses, and its role in tumor immunity has received extensive attention. Here, we review the mechanisms of the NLRP3 inflammasome enhancing CD8+ T cells-mediated anti-tumor immunity by inducing the pyroptosis of tumor cell, the pyroptosis or hyperactive state of dendritic cells (DCs), and the pyroptosis or polarization of the macrophages. Different anti-tumor immune roles of NLRP3 inflammasome activation in tumor cells and immune cells provide new directions for future research and may influence the development of next-generation immunotherapy.

NOD-like receptor protein 3  /  inflammasome  /  interleukin-1β  /  pyroptosis  /  dendritic cell  /  anti-tumor immunity
Cui-cui SUN, Jing-wen DONG, Ze-an KUANG, Ming-xiao YIN, Xiao-jia LIU, Hong-bin DENG. Research progresses on NLRP3 inflammasomes-induced anti-tumor immunity[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2612 -2621 . DOI: 10.16438/j.0513-4870.2022-0520
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Year 2022 volume 57 Issue 9
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doi: 10.16438/j.0513-4870.2022-0520
  • Receive Date：2022-04-29
  • Online Date：2025-12-24
  • Published：2022-09-12
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  • Received：2022-04-29
  • Revised：2022-06-20
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    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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